155511-82-3

Basic information

• Product Name: C₉H₁₅N₃
• Synonyms: C₉H₁₅N₃
• CAS NO: 155511-82-3
• Molecular Weight: 165.238
• Mol File: 155511-82-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₉H₁₅N₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₁₅N₃(155511-82-3)
• EPA Substance Registry System: C₉H₁₅N₃(155511-82-3)

Safety Data

• Hazardous Substances Data: 155511-82-3(Hazardous Substances Data)

Upstream product

• 822-36-6 4-methyl-1H-imidazole 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 

Downstream Products

• 911497-67-1 {5-(4-fluoro-3-methyl-phenyl)-4-[4-(5-methyl-1H-imidazol-4-yl)-piperidin-1-yl]-pyrimidin-2-yl}-acetonitrile 
• 335063-11-1 4-chloro-6-[4-(5-methyl-1H-imidazol-4-yl)-piperidin-1-yl]-5-phenyl-pyrimidine 

Relevant articles and documents

Synthesis and biological activity of 5-aryl-4-(4-(5-methyl-1H-imidazol-4-yl)piperidin-1-yl)pyrimidine analogs as potent, highly selective, and orally bioavailable NHE-1 inhibitors

A series of potent inhibitors of the sodium hydrogen exchanger-1 (NHE-1) is described. Structure-activity relationships identified the 3-methyl-4-fluoro analog 9t as a highly potent (IC50 = 0.0065 μM) and selective (NHE-2/NHE-1 = 1400) non-acylguanidine NHE-1 inhibitor. Pharmacokinetic studies showed that compound 9t has an oral bioavailability of 52% and a plasma half life of 1.5 h in rats. Because of its promising potency, selectivity, and a good pharmacokinetic profile, compound 9t was selected for further studies.