15555-77-8 Usage
Description
DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is an organometallic compound with the chemical formula [RuCl2(PPh3)3]. It is a versatile and widely used catalyst in various chemical reactions due to its unique properties and stability.
Uses
Used in Chemical Synthesis:
DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst for the selective hydrogenation of maleic anhydride or succinic anhydride, enabling the production of valuable chemicals with high selectivity and efficiency.
Used in Pharmaceutical Industry:
In the synthesis of portions of the natural antibiotic tetrodecamycin, DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst to facilitate the formation of the desired product, contributing to the development of new and effective antibiotics.
Used in Oxidation Reactions:
DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst for the oxidation of hydroxamic acid, a common reaction in the synthesis of various organic compounds and pharmaceuticals.
Used in Hydroesterification Reactions:
DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst in hydroesterification reactions, which are important for the production of esters and other valuable chemicals from alkenes and alcohols.
Used in Hydroboration of Alkenes:
DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst in the hydroboration of alkenes, a key reaction in the synthesis of various organic compounds, including pharmaceuticals and fine chemicals.
Used in Oxidation of Sulfide:
In the chemical industry, DICHLOROTRIS(TRIPHENYLPHOSPHINE)RUTHENIUM(II) is used as a catalyst for the oxidation of sulfide, a crucial step in the production of various sulfur-containing compounds and materials.
Check Digit Verification of cas no
The CAS Registry Mumber 15555-77-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,5,5 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 15555-77:
(7*1)+(6*5)+(5*5)+(4*5)+(3*5)+(2*7)+(1*7)=118
118 % 10 = 8
So 15555-77-8 is a valid CAS Registry Number.
InChI:InChI=1/4C18H15P.2ClH.Ru/c4*1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;;;/h4*1-15H;2*1H;/q;;;;;;+2/p-2
15555-77-8Relevant articles and documents
Design, synthesis, characterization and antiproliferative activities of Ru(II) complexes of substituted benzimidazoles
Singh, Ashok K.,Katheria, Snehlata,Kumar, Amrendra,Zafri, Asiff,Arshad, Mohd
, p. 2311 - 2318 (2019/09/04)
Synthesis of [Ru(PPh3)2(BZM)2Cl2] (BZM= LS1, LS2, LS3, LS4 and LS5) where LS1 = (1H-benzo[d]imidazole-2-yl)methanethiol, LS2 = 2-(4-bromobutyl)-1H-benzo[d]imidazole, LS3 = 2-(4-nitrophenyl)-1H-benzo[d]imidazole, LS4 = 2-(4-chlorophenyl)-1H-benzo[d]imidazole and LS5= 4-(1H-benzo[d]imidazol-2-yl)aniline (BZM = benzimidazoles, PPh3 = triphenylphosphine) and metal complexes as MR, [Ru (PPh3)4Cl2], MLS1, MLS2, MLS3, MLS4 and MLS5 for use as potential anticancer compounds have been investigated. The complexes have been characterized by elemental analysis, IR, multinuclear NMR, UV-visible and ESI-MS spectroscopic techniques. The geometries of all complexes have been optimized by using density functional theory (DFT). The cytotoxicity effects of MR, MLS2 and LS1 were also investigated on Human cervical carcinoma cells (HeLa) by MTT assay, ROS generation and nuclear apoptosis assay. The percent cell viability assessed by MTT assay suggested that the synthesized MR, MLS2 and LS1 significantly reduce the viability of HeLa cells, in a dose-dependent manner. The inhibitory concentration (IC50) of MR, MLS2 and LS1 against HeLa cells was found 90.8, 81.8 and 115 μM, respectively. These compounds also induced the over production of intracellular reactive oxygen species (ROS) as well as the condensed and fragmented nucleus, which supports the molecular mechanism of cell death by apoptosis. The investigations suggested that the compounds MR, MLS2 and LS1 induce the cell death in HeLa cells through apoptotic pathway.
