155557-30-5

Basic information

• Product Name: Propanedinitrile, [[(3-methoxyphenyl)amino](methylthio)methylene]-
• CAS NO: 155557-30-5
• Molecular Formula: C12H11N3OS
• Molecular Weight: 245.305
• Mol File: 155557-30-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanedinitrile, [[(3-methoxyphenyl)amino](methylthio)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedinitrile, [[(3-methoxyphenyl)amino](methylthio)methylene]-(155557-30-5)
• EPA Substance Registry System: Propanedinitrile, [[(3-methoxyphenyl)amino](methylthio)methylene]-(155557-30-5)

Safety Data

• Hazardous Substances Data: 155557-30-5(Hazardous Substances Data)

Upstream product

• 109-77-3 malononitrile 
• 3125-64-2 3-methoxyphenyl isothiocyanate 
• 74-88-4 methyl iodide 
• 536-90-3 m-Anisidine 
• 5147-80-8 [Bis(methylthio)methylene]malononitrile 

Downstream Products

• 1158183-36-8 C₁₂H₁₂N₆O 
• 183738-88-7 4-(3-Chloro-phenylamino)-3-(3-methoxy-phenylamino)-1H-pyrazolo[3,4-d]-pyrimidine 
• 824398-14-3 C₁₅H₁₂ClN₅O 
• 824398-98-3 7-(2-amino-2-methylpropylamino)-2-(3-methoxyphenylamino)-5-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 824397-82-2 2-(3-methoxyphenylamino)-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 170464-97-8 5-amino-3-(3-methoxyphenylamino)pyrazole-1H-4-carbonitrile 

Relevant articles and documents

Triflic acid-mediated N-heteroannulation of β-anilino-β-(methylthio)acrylonitriles: a facile synthesis of 4-amino-2-(methylthio)quinolines

Various functionalised 4-amino-2-(methylthio)quinolines are synthesised through triflic acid-mediated N-heteroannulation of α-functionalized-β-anilino-β-(methylthio)acrylonitriles for the first time. The N-heteroannulation process is highly chemoselective and has mild reaction conditions. However, this process fails in the absence of the β-methylthio group in the acrylonitriles. In addition, a new double N-heteroannulation process is demonstrated to synthesise indolo[3,2-c]quinolines from non-heterocyclic precursors. Natural product isocryptolepine is synthesised in four steps from an acyclic precursor.

Discovery of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives as c-Src kinase inhibitors for the treatment of acute ischemic stroke

We synthesized a series of novel 2-anilinopyrazolo[1,5-a]pyrimidine derivatives and evaluated their ability to inhibit c-Src kinase; 7-(2-amino-2-methylpropylamino)-5-cyclopropyl-2-(3,5-dimethoxyphenylamino) pyrazolo-[1,5-a]pyrimidine-3-carboxamide 7o and

PYRAZOLE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF

-