15568-73-7

Basic information

• Product Name: 5,5-dimethyl-3-(p-nitrophenyl)-1,4,2-dioxazole
• Synonyms: 5,5-dimethyl-3-(p-nitrophenyl)-1,4,2-dioxazole
• CAS NO: 15568-73-7
• Molecular Weight: 222.2
• Mol File: 15568-73-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5,5-dimethyl-3-(p-nitrophenyl)-1,4,2-dioxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-dimethyl-3-(p-nitrophenyl)-1,4,2-dioxazole(15568-73-7)
• EPA Substance Registry System: 5,5-dimethyl-3-(p-nitrophenyl)-1,4,2-dioxazole(15568-73-7)

Safety Data

• Hazardous Substances Data: 15568-73-7(Hazardous Substances Data)

Upstream product

• 1613-76-9 4-nitrobenzohydroxamic acid 
• 126-84-1 2,2-diethoxypropane 

Downstream Products

• 99-77-4 ethyl 4-nitrobenzoate 
• 1613-76-9 4-nitrobenzohydroxamic acid 

Relevant articles and documents

5,5-Dimethyl-1,4,2-dioxazoles as versatile aprotic hydroxamic acid protecting groups

5,5-Dimethyl-1,4,2-dioxazoles are readily installed by transketalization of 2,2-diethoxypropane, where both the NH and OH moieties are protected in a nonprotic form. The dioxazoles are stable to a wide variety of reaction conditions and readily revert back to the hydroxamic acid by treatment with Nafion-H in 2-propanol. The method is applicable to primary, secondary, tertiary, and aromatic hydroxamic acids, and the acidity of the protons adjacent to the dioxazole allows α-functionalization.