1557079-59-0

Basic information

• Product Name: 5-(7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-amine
• Synonyms: 5-(7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-amine
• CAS NO: 1557079-59-0
• Molecular Weight: 462.532
• Mol File: 1557079-59-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-amine(1557079-59-0)
• EPA Substance Registry System: 5-(7-(3-(methylsulfonyl)phenyl)-4-morpholinoquinazolin-2-yl)pyrimidin-2-amine(1557079-59-0)

Safety Data

• Hazardous Substances Data: 1557079-59-0(Hazardous Substances Data)

Upstream product

• 936250-22-5 (2-aminopyrimidin-5-yl)boronic acid 
• 1557083-89-2 4-(2-chloro-6-fluoro-7-(3-(methylsulfonyl)phenyl)quinazolin-4-yl)morpholine 

Relevant articles and documents

Substituted Amino-Pyrimidine Derivatives

The present application provides novel substituted quinazoline and pyrido-pyrimidine compounds and pharmaceutically acceptable salts, prodrugs, and solvates thereof. Also provided are methods for preparing these compounds. These compounds are useful in co-regulating PI3K and/or mTOR activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with the dysregulation of the PI3K/AKT/mTOR pathway. Advantageously, these compounds perform as dual PI3K/mTOR inhibitors. A variety of conditions can be treated using these compounds and include diseases which are characterized by inflammation or abnormal cellular proliferation. In one embodiment, the disease is cancer.