15582-97-5Relevant articles and documents
A Small-Molecule Inhibitor of Prion Replication and Mutant Prion Protein Toxicity
Massignan, Tania,Sangiovanni, Valeria,Biggi, Silvia,Stincardini, Claudia,Elezgarai, Saioa R.,Maietta, Giulia,Andreev, Ivan A.,Ratmanova, Nina K.,Belov, Dmitry S.,Lukyanenko, Evgeny R.,Belov, Grigory M.,Barreca, Maria Letizia,Altieri, Andrea,Kurkin, Alexander V.,Biasini, Emiliano
supporting information, p. 1286 - 1292 (2017/09/01)
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Efficient Trapping of 1,2-Cyclohexadienes with 1,3-Dipoles
Lofstrand, Verner A.,West, Frederick G.
supporting information, p. 10763 - 10767 (2016/07/27)
1,2-Cyclohexadienes are transient intermediates that undergo rapid dimerization and intermolecular trapping with activated olefins and heteroatomic nucleophiles. Fluoride-mediated desilylative elimination of readily accessible 6-silylcyclohexene-1-triflates allows the mild, chemoselective, and functional-group tolerant generation of cyclic allene intermediates, which undergo efficient trapping reactions with stable 1,3-dipoles. The reactions proceed with high levels of both regio- and diastereoselectivity. The reaction of cyclic allenes with azides is accompanied by the facile loss of dinitrogen, resulting in the formation of tetrahydroindoles or polycylic aziridines depending on the azide employed.
General and regioselective synthesis of pyrroles via ruthenium-catalyzed multicomponent reactions
Zhang, Min,Fang, Xianjie,Neumann, Helfried,Beller, Matthias
supporting information, p. 11384 - 11388 (2013/08/23)
A general and highly regioselective synthesis of pyrroles via ruthenium-catalyzed three-component reactions has been developed. A variety of ketones including less reactive aryl and alkyl substrates were efficiently converted in combination with different
