156001-73-9Relevant articles and documents
4-Aryl-substituted 2,5-dimethoxyphenethylamines: Synthesis and serotonin 5-HT2A receptor affinities
Trachsel, Daniel,Nichols, David E.,Kidd, Stephanie,Hadorn, Marcel,Baumberger, Franz
experimental part, p. 692 - 704 (2010/04/23)
A series of novel ligands for the serotonin 5-HT2A/C receptor subtype bearing the 2-phenylethylamine pharmacophore was synthesized and assayed for its 5-HT2A receptor binding affinity. As the 4′-arylsubstituted 2-(2,5-dimethoxyphenyl
ERβ ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives
Yang, Cuijian,Edsall Jr., Richard,Harris, Heather A.,Zhang, Xiaochun,Manas, Eric S.,Mewshaw, Richard E.
, p. 2553 - 2570 (2007/10/03)
A series of biphenyl carbaldehyde oximes (6) was prepared and shown to have significant selectivity for the estrogen receptor-β (ERβ). The exploitation of the oxime moiety as a hydrogen bond donating group, which mimicked the C-ring of genistein makes these compounds unique. Molecular modeling studies showed the oxime moiety hydrogen bonding to the histidine residue, which was supported by the structure-activity relationships. The most potent compounds in this study had IC50 values in a radioligand binding assay of between 8-35nM. Among the most selective compounds were 6i and 6s (49- and 31-fold ERβ selective, respectively).
A Fluorescent Self-Amplifying Wavelength-Responsive Sensory Polymer for Fluoride Ions
Kim, Tae-Hyun,Swager, Timothy M.
, p. 4803 - 4806 (2007/10/03)
A glowing response: Novel fluoride-selective sensors, utilizing fluoride-induced lactonization to highly fluorescent coumarin derivatives, are reported. The incorporation of this sensory system into a conjugated polymer amplifies the fluorescence response
