15601-88-4Relevant articles and documents
Synthesis method of drug for treating diabetes
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, (2018/06/23)
The invention relates to the fields of organic synthesis and pharmacy, and particularly relates to a synthesis method of a drug for treating diabetes. The synthesis method comprises the following steps of (1), hydrolyzing 2-cyanophenyl tert-butyl sulfide to produce o-carbamoylphenyl tert-butyl sulfide; (2), oxidizing the o-carbamoylphenyl tert-butyl sulfide to produce o-carbamoylphenyl tert-butylsulfoxide; (3), enabling the o-carbamoylphenyl tert-butyl sulfoxide to generate an intramolecular multicomponent reaction with phenyl isocyanide to produce 2-(aniline)-4H-benzo[e][1,3]thiazin-4-one. The synthesis method is simple, convenient and environmentally friendly, is easy to operate and suitable for industrialized production, and is low in cost and high in yield; synthesis raw materials areeasily obtained, and the atom economy is achieved.
Alkylation of 1,3-benzothiazin-4-one 2-oxo-, 2-arylimino-, and 2-thioxo derivatives
Shestakov, Alexandr S.,Prezent, Mikhail A.,Zlatoustovskaya, Evgenia O.,Shikhaliev, Khidmet S.,Falaleev, Alexandr V.,Sidorenko, Oleg E.
, p. 370 - 376 (2016/01/12)
[Figure not available: see fulltext.] Sodium salt of 3H -benzo[e][1,3]thiazine-2,4-dione is easily alkylated at position 3. In the case of 2-(arylimino)-2,3-dihydrobenzo[e][1,3]-thiazin-4-ones, the alkylation reaction at this position occurs regioselectively. Alkylation of 2-thioxo-2,3-dihydrobenzo[e][1,3]thiazin-4-one under the same conditions produced regioisomers, but S-alkylation at the exocyclic sulfur atom occurred in the presence of triethylamine. The reaction of 1-(4-oxo-3,4-dihydrobenzo[e][1,3]thiazin-2-ylidene)guanidine with methyl anthranilate led to the formation of tetracyclic quinazolino[2,1-b]quinazolinedione.
Novel Construction of 4H-2,3-Dihydro-1,3-benzothiazine Ring via Nickel(0)-Catalyzed Reaction of o-Iodobenzamide or o-Iodobenzonitrile with Thioureas
Takagi, Kentaro
, p. 2205 - 2206 (2007/10/02)
Nickel(0) complex induced the catalytic reaction of o-iodobenzamide or o-iodobenzonitrile with thioureas giving rise to cyclized products, 4H-2,3-dihydro-2-imino-1,3-benzothiazin-4-one or 4H-2,3-dihydro-1,3-benzothiazine-2,4-diimine.
