156046-05-8 Usage
Description
Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride is a complex organic chemical compound that exists as a salt form of the parent compound methyl (S)-4,4-difluoropyrrolidine-2-carboxylate. It is widely recognized for its role as a fundamental building block in the synthesis of pharmaceutical drugs, particularly due to its stability and ease of handling in medicinal chemistry research and drug development.
Uses
Used in Pharmaceutical Drug Synthesis:
Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride is utilized as a key intermediate in the creation of various pharmaceutical drugs. Its unique molecular structure allows it to be a versatile component in the development of new medications, contributing to the advancement of medical treatments.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, this hydrochloride salt is employed as a research compound to explore its potential pharmacological properties. Its application in research aids in understanding its interactions with biological systems and its possible role in the treatment of various diseases.
It is crucial to handle Methyl (S)-4,4-difluoropyrrolidine-2-carboxylate hydrochloride with care, adhering to stringent safety protocols and guidelines to ensure the safety of researchers and the effectiveness of the applications in which it is involved.
Check Digit Verification of cas no
The CAS Registry Mumber 156046-05-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,0,4 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 156046-05:
(8*1)+(7*5)+(6*6)+(5*0)+(4*4)+(3*6)+(2*0)+(1*5)=118
118 % 10 = 8
So 156046-05-8 is a valid CAS Registry Number.
156046-05-8Relevant articles and documents
Synthesis of (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives from (S)-aspartic acid
Burger, Klaus,Rudolph, Martin,Fehn, Susanna,Sewald, Norbert
, p. 87 - 90 (1994)
Syntheses for (2S)-4,4-difluoroproline, (2S,4R)-4-fluoroproline and their derivatives are described starting from (S)-aspartic acid, using hexafluoroacetone as the protecting reagent and DAST as the fluorinating agent.
Origin of the stability conferred upon collagen by fluorination
Shoulders, Matthew D.,Kamer, Kimberli J.,Raines, Ronald T.
supporting information; experimental part, p. 3859 - 3862 (2010/03/03)
According to a prevailing theory, (2S,4R)-4-hydroxyproline (Hyp) residues stabilize the collagen triple helix via a stereoelectronic effect that preorganizes appropriate backbone torsion angles for triple-helix formation. This theory is consistent with th
