156052-68-5

Basic information

• Product Name: ZOXAMIDE
• Synonyms: ZOXAMIDE;rh-7281;zoxamide (bsi,iso);Zoxamid;Zoxamide Solution, 100ppm;Zoxamide Solution, 1000ppm
• CAS NO: 156052-68-5
• Molecular Formula: C₁₄H₁₆Cl₃NO₂
• Molecular Weight: 336.64
• Mol File: 156052-68-5.mol
• Article Data: 7

Chemical Properties

• Melting Point: 158-160°; mp 159.5-160.5° (Egan)
• Boiling Point: 415.4°Cat760mmHg
• Flash Point: 205°C
• Appearance: /
• Density: 1.289g/cm³
• Vapor Pressure: 4.13E-07mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 0-6°C
• PKA: 11.20±0.46(Predicted)
• BRN: 11413911
• CAS DataBase Reference: ZOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ZOXAMIDE(156052-68-5)
• EPA Substance Registry System: ZOXAMIDE(156052-68-5)

Safety Data

• Hazard Codes: Xi,N
• Statements: 43-50/53
• Safety Statements: 24-37-46-60-61
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 156052-68-5(Hazardous Substances Data)

Usage

Description

Zoxamide, a chemical compound with fungicidal properties, is specifically designed to target Oomycete fungi. It is characterized by its strong preventive activity, excellent rainfast properties, and effective residual action, making it a valuable asset in agricultural applications.

Uses

Used in Agricultural Industry:
Zoxamide is used as a fungicide for the control of mildew and late blight. It was developed for foliar use on a variety of crops, including potatoes, vines, and vegetables, to protect them from fungal infections and ensure a healthy yield.
Zoxamide is used as a targeted fungicide for Oomycete fungi, providing strong preventive activity and excellent rainfast and residual properties, which are crucial for maintaining the effectiveness of the treatment even under challenging weather conditions.

Hazard

Low toxicity by ingestion, inhalation, and skin contact.

InChI:InChI=1/C14H16Cl3NO2/c1-4-14(3,12(19)7-15)18-13(20)9-5-10(16)8(2)11(17)6-9/h5-6H,4,7H2,1-3H3,(H,18,20)

Upstream product

• 209809-70-1 2-(3,5-dichloro-4-methylphenyl)-4-ethyl-4-methyl-5-methyleneoxazoline 
• 87-90-1 trichloroisocyanuric acid 
• 39652-34-1 3,5-dichloro-4-methylbenzoic acid 
• 113485-46-4 3,5-dichloro-4-methylbenzoyl chloride 

Downstream Products

• 160171-18-6 (+)-S-zoxamide 
• 160171-18-6 (-)-R-zoxamide 

Relevant articles and documents

Method for preparing benzamide compound

The invention provides a method for preparing a benzamide compound, and belongs to the technical field of organic synthesis. The method for preparing a benzamide compound provided by the invention comprises the following steps: mixing aryl-substituted dihydrooxazole, an acidic catalyst, water and a reaction solvent, and carrying out hydrolysis ring-opening reaction to obtain the benzamide compound, wherein the acidic catalyst is p-toluenesulfonic acid or sulfonic acid ion exchange resin. According to the invention, p-toluenesulfonic acid or sulfonic acid ion exchange resin is used as an acidiccatalyst, under the catalytic action of the p-toluenesulfonic acid or sulfonic acid ion exchange resin, aryl-substituted dihydrooxazole is subjected to hydrolysis ring-opening reaction to obtain thebenzamide compound, only metered toluenesulfonic acid or sulfonic acid ion exchange resin needs to be catalyzed, the toluenesulfonic acid or sulfonic acid ion exchange resin is convenient to remove after the reaction is completed, almost no waste is generated, and industrial production is convenient to achieve.

Metal salt catalyzed process to oxazolines and subsequent formation of chloroketones

This invention relates to a process for the preparation of an α-chloroketone compound comprising the steps of (i) cyclizing an alkynyl amide to form a 5-methyleneoxazoline (ii) chlorinating the 5-methyleneoxazoline using trichloroisocyanuric acid to produce a chlorinated oxazoline intermediate and (iii) hydrolyzing the chlorinated oxazoline intermediate with an aqueous acid to produce the desired monochloroketone wherein Z is alkyl or substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl or phenylene, R is a hydrogen atom or alkyl, and R1and R2are each independently an alkyl or substituted alkyl group, or R1and R2together with the carbon atom to which they are attached form a cyclic structure. Additionally, when R is a hydrogen atom, a dichloroketone can be conveniently formed through adjustment of reaction conditions.

Development of a process for triazine-promoted amidation of carboxylic acids

A process has been developed for the triazine-promoted amidation of carboxylic acids. We have identified 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) as a cost-effective reagent for this transformation. The procedure is a suitable alternative to traditional amidation processes when an acid chloride cannot be prepared from the corresponding carboxylic acid due to safety, stability, or handling concerns.