1560840-75-6

Basic information

• Product Name: N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy)phenyl) acetamide
• Synonyms: N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy)phenyl) acetamide
• CAS NO: 1560840-75-6
• Molecular Weight: 352.349
• Mol File: 1560840-75-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy)phenyl) acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy)phenyl) acetamide(1560840-75-6)
• EPA Substance Registry System: N-(4-(4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2-(3H)-yl)-2-methylphenoxy)phenyl) acetamide(1560840-75-6)

Safety Data

• Hazardous Substances Data: 1560840-75-6(Hazardous Substances Data)

Upstream product

• 1352755-63-5 2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 955010-26-1 2-(4-(4-aminophenoxy)-3-methylphenyl)-1,2,4-triazine-3,5-(2H,4H)-dione 
• 75-36-5 acetyl chloride 
• 100-00-5 4-chlorobenzonitrile 
• 175971-60-5 2-(3-Methyl-4-hydroxyphenyl)-1,2,4-triazine-3,5(2H,4H)-dione 
• 103-90-2 4-acetaminophenol 
• 13290-74-9 1-chloro-2-methyl-4-nitrobenzene 
• 57715-76-1 2-(4-chloro-3-methyl-phenyl)-2H-[1,2,4]triazine-3,5-dione 
• 7149-75-9 3-methyl-4-chloroaniline 
• 455-88-9 5-nitro-2-fluorotoluene 
• 7279-45-0 dichloroacetyl-carbamic acid ethyl ester 

Relevant articles and documents

Preparation method of Ethanamizuril bulk drug

The invention provides a preparation method of a Ethanamizuril bulk drug, which comprises the following steps: reacting acetaminophen and 2-fluoro-5-nitrotoluene as initial raw materials to obtain a compound II, and carrying out diazotization coupling reaction to obtain a compound IV, wherein the conjugate adopted in the diazotization coupling reaction is a compound III. According to the preparation method of the Ethanamizuril bulk drug, malonic acid monoester monoamide formate is used as a conjugate, acetaminophen and 2-fluoro-5-nitrotoluene are used as initial raw materials, construction ofa triazine ring can be realized more efficiently and mildly, and the obtained target product samipril is higher in yield and purity.

Preparation method of triazinone ring

A preparation method of a triazinone ring relates to the technical field of veterinary drugs, and comprises the following steps: carrying out a diazo condensation reaction on a condensation compound aniline and potassium ethyl malonate, carrying out an amidation reaction with sodium cyanate under an acidic condition, adding acetic acid and sodium acetate, heating, heating, and carrying out a cyclization reaction to obtain a triazinone compound. According to the method, operations such as filtration and separation are not needed before the finished product is obtained, the product loss is reduced, the method has the advantages of simple process and high yield, the yield of the salmizuril can reach 89.65%-94.81%, and the yield of the diclazuril can reach 80.20%-94.11%; and the problem of odor generation of decarboxylation reaction in the production process is also solved, and the method is beneficial to environmental protection and suitable for industrial production.

Green synthesis method of anticoccidial veterinary drug Ethanamizuril

The invention relates to a green synthesis method of anticoccidial veterinary drug Ethanamizuril, and solves the technical problems that in the prior art, an Ethanamizuril production method needs tensteps of reaction, the reaction steps are complex, the raw materials are difficult to obtain and high in price, the investment is large, the yield is low, the product quality is poor, the color is poor, and the method is not suitable for industrial production. According to the green synthesis method of anticoccidial veterinary drug Ethanamizuril, 4-chloro-3-methylaniline and EPC are taken as initial raw materials, diazo coupling, cyclization, hydrolysis, decarboxylation and condensation reaction are carried out to obtain the product Ethanamizuril. The method is widely applied to the technicalfield of veterinary drug synthesis.