156121-15-2

Basic information

• Product Name: 2-Methoxymethylmorpholine
• Synonyms: 2-Methoxymethylmorpholine;Morpholine, 2-(MethoxyMethyl)-
• CAS NO: 156121-15-2
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131
• Mol File: 156121-15-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 196℃
• Flash Point: 70℃
• Appearance: /
• Density: 0.954
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 2-Methoxymethylmorpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxymethylmorpholine(156121-15-2)
• EPA Substance Registry System: 2-Methoxymethylmorpholine(156121-15-2)

Safety Data

• Hazardous Substances Data: 156121-15-2(Hazardous Substances Data)

Usage

General Description

2-Methoxymethylmorpholine is a chemical compound with the molecular formula C6H13NO2. It is a derivative of morpholine and is often used as a solvent in various industrial applications such as in the production of adhesives, plastics, and resins. It is also known for its use as a corrosion inhibitor in water treatment and as a stabilizer for dyes and pigments. Additionally, 2-Methoxymethylmorpholine has been found to exhibit antifungal and antimicrobial properties, making it useful in the formulation of agricultural products and pharmaceuticals. Overall, this chemical compound has a wide range of industrial and agricultural applications due to its solvent and stabilizing properties.

Upstream product

• 135065-69-9 tert-butyl 2-(hydroxymethyl)morpholine-4-carboxylate 
• 768371-16-0 4-(tert-butyl) 2-ethyl morpholine-2,4-dicarboxylate 
• 40987-25-5 N-benzyl-2-chloromethylmorpholine 
• 176093-22-4 1-[Benzyl-(2-hydroxy-ethyl)-amino]-3-methoxy-propan-2-ol 
• 143804-53-9 4-benzyl-2-(methoxymethyl)morpholine 

Relevant articles and documents

HPK1 ANTAGONISTS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of HPK1, and the treatment of HPK1-mediated disorders.

Synthesis and antibacterial activity of thiazolopyrazine-incorporated tetracyclic quinolone antibacterial agents. 2

A novel series of 8-(2-substituted morpholino)-9,1-[(N- methylimino)methano]-7-fluoro-5-oxo-5H-thiazolo[3,2-α]quinoline-4- carboxylic acids, designated 8a-j, with a unique tetracyclic structure were synthesized, and the in vitro and in vivo antibacterial activities against Gram-positive strains, including methicillin-resistant Staphylococcus aureus isolates (MRSA), and Gram-negative strains were evaluated. These morpholino derivatives, 8a-j, showed excellent in vitro antibacterial activities against Gram-positive bacteria. The substitutions at the C-2 position of the 8- morpholino moiety of compound 8 play an important role in the enhancement of in vivo antibacterial activity. The unsubstituted morpholino derivative 8a, the 2,6-dimethyl derivative 8c, and the 2-ethylmorpholino derivative 8d showed poor in vivo antibacterial activity, while 8b, 8f-h, and 8j exhibited good activities. The 2-(methoxymethyl)morpholino derivative, 8h, showed the most potent activity in vivo. The therapeutic effects of 8h on systemic infection against S. aureus IID 803 were over 10-fold more potent than that of ofloxacin. Compound 8h, which showed superior oral bioavailability, has a chiral center. The enantiomers of 8h were synthesized, and the in vitro and in vivo antibacterial activities were evaluated. Both enantiomers, (S)-8h and (R)-8h, and the racemic compound 8 exhibited similar activities in vitro and in vivo. Compounds 8b and 8f-h also showed good levels of antibacterial activity against MRSA strains. The morpholino derivatives with unique tetracyclic structures are characterized by strong antibacterial activities against MRSA strains.