156186-40-2Relevant articles and documents
Nickel-Catalyzed Alkylation of Ketone Enolates: Synthesis of Monoselective Linear Ketones
Das, Jagadish,Vellakkaran, Mari,Banerjee, Debasis
, p. 769 - 779 (2019/01/24)
Herein we have developed a Ni-catalyzed protocol for the synthesis of linear ketones. Aryl, alkyl, and heteroaryl ketones as well as alcohols yielded the monoselective ketones in up to 90% yield. The catalytic protocol was successfully applied in to a gram-scale synthesis. For a practical utility, applications of a steroid derivative, oleyl alcohol, and naproxen alcohol were employed. Preliminary catalytic investigations involving the isolation of a Ni intermediate and defined Ni-H species as well as a series of deuterium-labeling experiments were performed.
ALLOSTERIC PROTEIN KINASE MODULATORS
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Page/Page column 126, (2010/04/30)
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions comprising same, and their use for preparing medicaments for the treatment and prevention of diseases related to abnormal activities of AGC protein kinases or of protein kinases of the Aurora family.
Isolation and characterisation of aromatic substituted olefinic compounds from the starfish Pteraster militaris
Yayli, Nurettin
, p. 556 - 561 (2007/10/03)
Two series of the polyaromatic coumpound (1-6 and 7-14) have been isolated from the starfish Pteraster militaris after column chromatography over Amberlite XAD-2 resin.Their structures have been established by spectroscopic means and confirmed as 2,4-diph