1563182-64-8

Basic information

• Product Name: (S)-benzyl 2-(2-(methylamino)-3-phenylpropanamido)ethylcarbamate
• Synonyms: (S)-benzyl 2-(2-(methylamino)-3-phenylpropanamido)ethylcarbamate
• CAS NO: 1563182-64-8
• Molecular Weight: 355.437
• Mol File: 1563182-64-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-benzyl 2-(2-(methylamino)-3-phenylpropanamido)ethylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl 2-(2-(methylamino)-3-phenylpropanamido)ethylcarbamate(1563182-64-8)
• EPA Substance Registry System: (S)-benzyl 2-(2-(methylamino)-3-phenylpropanamido)ethylcarbamate(1563182-64-8)

Safety Data

• Hazardous Substances Data: 1563182-64-8(Hazardous Substances Data)

Upstream product

• 1563182-63-7 (S)-tert-butyl (1-((2-(((benzyloxy)carbonyl)amino)ethyl)amino)-1-oxo-3-phenylpropan-2-yl)(methyl)carbamate 
• 37553-65-4 Boc-N-Me-Phe-OH 
• 2566-30-5 N-Methyl-L-phenylalanine 
• 501-53-1 benzyl chloroformate 
• 1161-13-3 N-Cbz-L-Phe 

Downstream Products

• 1563182-77-3 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-N-methylbutanamido)-3-phenylpropanamido)ethylcarbamic acid benzyl ester 
• 1563182-78-4 2-((S)-2-((S)-2-(3,4-dichlorophenyl)-4-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-N-methylbutanamido)-3-phenylpropanamido)ethylcarbamic acid benzyl ester 
• 1563182-79-5 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-5-hydroxy-N-methylpentanamido)-3-phenylpropanamido)-ethyl carbamic acid benzylester 
• 1563182-81-9 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-N-methyl-5-oxopentanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563182-83-1 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-5-(6-fluoro-1-methyl-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidine]-1'-yl)-N-methylpentanamido)-3-phenylpropanamido)ethylcarbamic acid benzyl ester 
• 1563182-89-7 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-4-(6'-fluoro-1'-methyl-2'-oxo-1',2'-dihydrospiro[azetidine-3,4'-benzo[d][1,3]oxazine]-1-yl)-N-methylbutanamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563536-26-4 (R)-N-((S)-1-(2-aminoethylamino)-1-oxo-3-phenylpropan-2-yl)-2-(3,4-dichlorophenyl)-4-(6'-fluoro-1'-methyl-2'-oxo-1',2'-dihydrospiro [azetidine-3,4'-benzo[d][1,3]oxazine]-1-yl)-N-methylbutanamide dihydrochloride 
• 1563182-65-9 2-((S)-2-((R)-2-(3,4-dichlorophenyl)-N-methylpent-4-enamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 
• 1563182-66-0 2-((S)-2-((S)-2-(3,4-dichlorophenyl)-N-methylpent-4-enamido)-3-phenylpropanamido)ethyl carbamic acid benzyl ester 

Relevant articles and documents

Design, synthesis, and optimization of balanced dual NK1/NK 3 receptor antagonists

In connection with a program directed at potent and balanced dual NK 1/NK3 receptor ligands, a focused exploration of an original class of peptidomimetic derivatives was performed. The rational design and molecular hybridization of a novel phenylalanine core series was achieved to maximize the in vitro affinity and antagonism at both human NK1 and NK3 receptors. This study led to the identification of a new potent dual NK1/NK3 antagonist with pKi values of 8.6 and 8.1, respectively.