156349-08-5

Basic information

• Product Name: 4-(2-(1-propylamino)ethyl)phenol
• Synonyms: 4-(2-(1-propylamino)ethyl)phenol
• CAS NO: 156349-08-5
• Molecular Weight: 179.262
• Mol File: 156349-08-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2-(1-propylamino)ethyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(1-propylamino)ethyl)phenol(156349-08-5)
• EPA Substance Registry System: 4-(2-(1-propylamino)ethyl)phenol(156349-08-5)

Safety Data

• Hazardous Substances Data: 156349-08-5(Hazardous Substances Data)

Upstream product

• 107-10-8 propylamine 
• 14140-15-9 4-(2-bromoethyl)phenol 
• 156-38-7 4-hydroxyphenylacetate 
• 139181-36-5 N-(1-propyl)-4-hydroxyphenylacetamide 

Downstream Products

• 1173289-66-1 (S)-2-(3-benzoylphenyl)-N-(4-hydroxyphenethyl)-N-propylpropanamide 

Relevant articles and documents

Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription

We report novel inhibitors of Gli1-mediated transcription as potential anticancer agents. Focused chemical libraries were designed and assessed for inhibition of functional cell-based Gli1-mediated transcription and selective toxicity toward cancer cells. The SAR was revealed, and the selectivity of the lead compounds' inhibition of Gli1-mediated transcription over that of Gli2 was determined. Compound 63 (NMDA298-1), which inhibited Gli1-mediated transcription in C3H10T1/2 cells with an IC50 of 6.9 μM, showed 3-fold selectivity for inhibiting transcription mediated by Gli1 over that by Gli2. Cell-viability assays were performed to evaluate the chemical library in a normal cell line and a panel of cancer cell lines with or without up-regulated expression of the Gli1 gene. These compounds decreased the viability of several cancer cell lines but were less active in the noncancerous BJ-hTERT cells. 2009 American Chemical Society.