156357-14-1

Basic information

• Product Name: 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
• Synonyms: 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine
• CAS NO: 156357-14-1
• Molecular Weight: 492.466
• Mol File: 156357-14-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine(156357-14-1)
• EPA Substance Registry System: 2,6-diamino-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine(156357-14-1)

Safety Data

• Hazardous Substances Data: 156357-14-1(Hazardous Substances Data)

Upstream product

• 156357-13-0 2,6-diazido-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine 
• 5451-40-1 2,6-dichloro-7H-purine 
• 156357-16-3 2,6-dichloro-9-(3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine 
• 149623-91-6 1-O-acetyl-3,5-di-O-benzoyl-2-deoxy-2-fluoro-β-D-ribofuranoside 

Downstream Products

• 147048-53-1 2'-Deoxy-2,2'-difluoro-adenosine 
• 78842-13-4 2'-deoxy-2'-fluoroguanosine 
• 156357-17-4 2'-deoxy-3',5'-di-O-benzoyl-2,2'-difluoroadenosine 
• 134444-47-6 2,6-diamino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)-9H-purine 

Relevant articles and documents

Synthesis and biologic activity of purine 2'-deoxy-2'-fluoro- ribonucleosides

The synthesis of 3,5-di-O-benzoyl-2-deoxy-2-fluoro-D-ribofuranosyl bromide (8) and its reaction with 2,6-dichloropurine by fusion and with mercuric cyanide catalysis is described. The resulting 2,6-dichloro-9-(3,5-di-O- benzoyl-2-deoxy-2-fluoro-β-D-ribofuranosyl)purine (13) was converted to the 2-fluoroadenine (16), the 2-chloroadenine (17), 2,6-diaminopurine (12), and guanine (14) nucleosides by standard procedures. These nucleosides were cytotoxic to a number of cell lines in culture. The 2-haloadenine nucleosides 16 and 17 gave modest increases in lifespan when tested against the P388 leukemia in mice.