156496-64-9

Basic information

• Product Name: 1-[4-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde
• Synonyms: 1-[4-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde
• CAS NO: 156496-64-9
• Molecular Weight: 239.197
• Mol File: 156496-64-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-[4-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(156496-64-9)
• EPA Substance Registry System: 1-[4-(trifluoromethyl)phenyl]-1H-pyrrole-3-carbaldehyde(156496-64-9)

Safety Data

• Hazardous Substances Data: 156496-64-9(Hazardous Substances Data)

Usage

Appearance

White to off-white solid

Molecular Weight

241.19 g/mol

Functional Groups

Pyrrole derivative
Trifluoromethylphenyl group
Carbaldehyde functional group

Usage

Building block in organic synthesis and pharmaceutical research

Potential Applications

Drug discovery and development

Safety Precautions

Handle with caution and under proper safety measures due to potential toxicity and reactivity

Upstream product

• 156496-70-7 1-(4-trifluoromethyl-phenyl)-pyrrole-2-carbaldehyde 
• 50634-05-4 2,5-dimethoxy-3-tetrahydrofurancarboxaldehyde 
• 455-14-1 4-trifluoromethylphenylamine 

Downstream Products

• 1186528-62-0 C₂₉H₃₀F₃N₅O 
• 1186528-61-9 C₂₈H₃₆F₃N₅O₂ 
• 1186528-60-8 C₂₈H₃₅F₃N₄O₃ 
• 1186528-59-5 C₂₉H₃₇F₃N₄O₂ 
• 1186528-58-4 C₂₉H₃₇F₃N₄O₂ 
• 1186528-57-3 C₂₇H₃₅F₃N₄O₂ 
• 1186528-56-2 C₂₅H₂₄Cl₂F₃N₃O₂ 
• 1186528-54-0 C₂₅H₂₅ClF₃N₃O₂ 
• 1186528-53-9 C₂₆H₃₄F₃N₃O₂ 
• 1186528-49-3 C₂₉H₃₃F₄N₃O₂ 
• 1186528-67-5 C₃₀H₃₇F₃N₄O₂ 
• 1186528-66-4 C₃₁H₃₀F₄N₄O₂ 
• 1186528-65-3 C₃₁H₃₀F₄N₄O 
• 1186528-64-2 C₃₁H₃₀ClF₃N₄O 

Relevant articles and documents

Discovery and structure-activity relationships of pyrrolone antimalarials

In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.

N-PIPERIDINE DERIVATES AS CCR3 MODULATORS

Compounds of formula I, processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dement

Novel HIV-1 protease inhibitors active against multiple PI-Resistant viral strains: Coadministration with indinavir

HIV-1 protease inhibitors (PI) with an N-arylpyrrole moiety in the P 3 position afforded excellent antiviral potency and substantially improved aqueous solubility over previously reported variants. The rapid in vitro clearance of these compounds in human liver microsomes prompted oral coadministration with indinavir to hinder their metabolism by the cyctochrome P450 3A4 isozyme and allow for in vivo PK assessment.