1565804-14-9

Basic information

• Product Name: Ac-Glu(O^tBu)-Ala-Arg(Pmc)-Lys(Boc)-Thr(Trt)-OH
• Synonyms: Ac-Glu(O^tBu)-Ala-Arg(Pmc)-Lys(Boc)-Thr(Trt)-OH
• CAS NO: 1565804-14-9
• Molecular Weight: 1310.62
• Mol File: 1565804-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Ac-Glu(O^tBu)-Ala-Arg(Pmc)-Lys(Boc)-Thr(Trt)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Ac-Glu(O^tBu)-Ala-Arg(Pmc)-Lys(Boc)-Thr(Trt)-OH(1565804-14-9)
• EPA Substance Registry System: Ac-Glu(O^tBu)-Ala-Arg(Pmc)-Lys(Boc)-Thr(Trt)-OH(1565804-14-9)

Safety Data

• Hazardous Substances Data: 1565804-14-9(Hazardous Substances Data)

Upstream product

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 108-24-7 acetic anhydride 
• 71989-26-9 Fmoc-Lys(tert-butoxycarbonyl) 
• 133180-01-5 Fmoc-O-trityl-l-threonine 
• 119831-72-0 Fmoc-Arg(Pbf)-OH 

Downstream Products

• 1565804-15-0 C₈₉H₁₂₂N₁₂O₁₉S 

Relevant articles and documents

Design and synthesis of peptide-MCA substrates for a novel assay of histone methyltransferases and their inhibitors

Histone methyltransferases (HMTs) play an important role in controlling gene expression through site-specific methylation of lysines in core and linker histones within chromatin. As the typical HMTs, G9a and Set7/9 have been intensively studied that G9a is specific to the methylation at H3K9 and H3K27 and represses transcription, while Set7/9 methylates at H3K4. In this report we prepared various peptide-MCAs (4-methylcoumaryl-7-amides) related to histone tail and protein-substrates such as p53 and estrogen receptor-α. The fluorogenic substrates are applied for the assay of HMTs and an inhibitor, for example. The most sensitive and specific MCA-substrates to G9a and Set7/9 are discovered. The peptide-MCAs corresponding to the methylation sequences are promising for screening of HMT inhibitors.