156628-72-7Relevant articles and documents
Synthesis of a series of mono-meso-arylmesoporphyrins III of biological interest and their biliverdin derivatives
Niemevz, Fernando,Vazquez, Ma. Soledad,Buldain, Graciela Y.
, p. 875 - 882 (2008/09/21)
Synthesis of a series of mono-meso-arylmesoporphyrins III using a MacDonald-type 2+2 condensation is described. In this method, the substituted 1,9-diformyldipyrromethane is treated with a dipyrromethane-1,9-dicarboxylic acid under acidic conditions. The 5-aryldipyrrolic unit was obtained by condensation of tert-butyl, ethyl, or benzyl 4-ethyl-3-methyl-1H-pyrrole-2- carboxylate with different aromatic aldehydes in the presence of 4-toluene-sulfonic acid. In order to obtain the corresponding mesobiliverdins, chemical oxidation of each mesoporphyrin was carried out. Each meso-arylmesoporphyrin rendered two isomeric arylbiliverdins, as the porphyrin meso-aryl bridge is not cleaved. Georg Thieme Verlag Stuttgart.