1566577-46-5

Basic information

• Product Name: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione
• Synonyms: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione
• CAS NO: 1566577-46-5
• Molecular Weight: 277.255
• Mol File: 1566577-46-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(1566577-46-5)
• EPA Substance Registry System: (E)-5-((dimethylamino)methylene)-1-(4-fluorophenyl)pyrimidine-2,4,6-trione(1566577-46-5)

Safety Data

• Hazardous Substances Data: 1566577-46-5(Hazardous Substances Data)

Upstream product

• 659-30-3 1-(4-fluorophenyl)urea 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 19136-41-5 1-(4-fluorophenyl)pyrimidine-2,4,6-trione 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1566577-78-3 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-morpholinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)trione 
• 1566577-86-3 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)quinoline-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-62-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(4-methyl-1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-70-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1566577-54-5 1-(4-fluorophenyl)-5-((3-fluoro-4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)quinolin-4-oxy)phenylamino)methylene)pyrimidine-2,4,6(1H,3H,5H)-trione 

Relevant articles and documents

Discovery of novel 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 5-(aminomethylene)pyrimidine-2,4,6-trione moiety as c-Met kinase inhibitors

A series of novel quinoline derivatives bearing 5-(aminomethylene) pyrimidine-2,4,6-trione moiety were designed, synthesized, and evaluated for their c-Met kinase inhibitory activities and antiproliferative activities against 5 cancer cell lines (HT-29, H460, MKN-45, A549, and U87MG) in vitro. Most compounds showed moderate to excellent potency, with the most promising analogue 45 (c-Met half-maximal inhibitory concentration [IC50] = 1.15 nM) showing high selectivity versus 5 other tyrosine kinases, VEGFR-2, Flt-3, PDGFR-β, c-Kit, and EGFR. Structure-activity relationship studies indicated that electron-donating groups on the phenyl ring at the 3-position of pyrimidine-2,4,6-trione were required to increase the electron density on the 5-(aminomethylene)pyrimidine-2,4,6-trione moiety.