1567317-51-4Relevant articles and documents
Synthesis, crystal structure, DNA cleavage properties, and protein binding activities of an unsymmetrical dinuclear copper(II) complex
Lu, Jing,Li, Jun-Ling,Sun, Qian,Jiang, Lin,Wang, Bi-Wei,Gu, Wen,Liu, Xin,Tian, Jin-Lei,Yan, Shi-Ping
, p. 300 - 314 (2014)
[Cu2L(phen)(H2O) 3(ClO4)] (ClO4)3 {phen = 1,10-phenanthroline, L = 4-((bis(pyridine2-ylmethyl)amino)methyl)-N,N-bis(pyridin-2-ylmethyl)aniline} was prepared and characterized by physical chemical techniques. The X-ray single-crystal structure analysis shows an unsymmetrical dinuclear species. The interaction of the complex with calfthymus DNA (CT-DNA) was studied by various spectroscopic and viscosity measurements, which indicate that the complex can interact with CT-DNA through intercalation. In the presence of H 2O2, the complex can cleave pBR322 DNA more efficiently and hydroxyl radicals (HO.) may serve as the major cleavage active species. Interactions of the compound with bovine serum albumin (BSA) were also investigated using UV-Vis and fluorescence spectroscopic methods. The results show that the complex quenches the intrinsic fluorescence of BSA by a static quenching mechanism. 2014