1567711-33-4

Basic information

• Product Name: 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole
• Synonyms: 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole
• CAS NO: 1567711-33-4
• Molecular Weight: 444.605
• Mol File: 1567711-33-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole(1567711-33-4)
• EPA Substance Registry System: 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole(1567711-33-4)

Safety Data

• Hazardous Substances Data: 1567711-33-4(Hazardous Substances Data)

Upstream product

• 3096-81-9 4-phenoxybenzonitrile 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 108-95-2 phenol 
• 3058-39-7 4-iodobenzonitrile 
• 1136832-73-9 (Z)-N′-hydroxy-4-phenoxybenzamidine 
• 90446-67-6 4-((tert-butyldimethylsilyl)oxy)benzoyl chloride 
• 78324-14-8 tert-butyldimethylsilyl 4-((tert-butyldimethylsilyl)oxy)benzoate 

Downstream Products

• 1136832-74-0 5-(4-(tert-butyldimethylsilyloxy)phenyl)-3-(4-phenoxyphenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with gram-positive antibacterial activity

Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. We disclose herein the discovery of a new class of non-β-lactam antibiotics, the oxadiazoles, which inhibit penicillin-binding protein 2a (PBP2a) of MRSA. The oxadiazoles show bactericidal activity against vancomycin-and linezolid-resistant MRSA and other Gram-positive bacterial strains, in vivo efficacy in a mouse model of infection, and have 100% oral bioavailability.