1567836-38-7

Basic information

• Product Name: 2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide
• Synonyms: 2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide
• CAS NO: 1567836-38-7
• Molecular Weight: 497.546
• Mol File: 1567836-38-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide(1567836-38-7)
• EPA Substance Registry System: 2,4-difluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzenesulfonamide(1567836-38-7)

Safety Data

• Hazardous Substances Data: 1567836-38-7(Hazardous Substances Data)

Upstream product

• 552330-86-6 5-bromoisoindolin-1-one 
• 99548-55-7 4-bromo-2-methyl-benzoic acid methyl ester 
• 68837-59-2 4-bromo-2-methylbenzoic acid 
• 78471-43-9 methyl 4-bromo-2-(bromomethyl)benzoate 
• 1567836-37-6 5-(5-(5-aminopyridin-3-yl)thiophen-2-yl)-2-methylisoindolin-1-one 
• 13918-92-8 2,4-difluorobenzene-1-sulfonyl chloride 
• 1567836-36-5 5-(5-iodothiophen-2-yl)-2-methylisoindolin-1-one 
• 1567836-35-4 2-methyl-5-(thiophen-2-yl)isoindolin-1-one 
• 868066-91-5 5-bromo-2-methyl-1,3-dihydroisoindol-1-one 

Relevant articles and documents

Benzenesulphonamide inhibitors of the cytolytic protein perforin

The pore-forming protein perforin is a key component of mammalian cell-mediated immunity and essential to the pathway that allows elimination of virus-infected and transformed cells. Perforin activity has also been implicated in certain auto-immune conditions and therapy-induced conditions such as allograft rejection and graft versus host disease. An inhibitor of perforin activity could be used as a highly specific immunosuppressive treatment for these conditions, with reduced side-effects compared to currently accepted therapies. Previously identified first-in-class inhibitors based on a 2-thioxoimidazolidin-4-one core show suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. The current benzenesulphonamide-based series delivers a non-toxic bioisosteric replacement possessing improved solubility.