156897-26-6

Basic information

• Product Name: 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine
• Synonyms: 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine
• CAS NO: 156897-26-6
• Molecular Weight: 343.512
• Mol File: 156897-26-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(156897-26-6)
• EPA Substance Registry System: 6-(4-tert-Butyl-phenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine(156897-26-6)

Safety Data

• Hazardous Substances Data: 156897-26-6(Hazardous Substances Data)

Upstream product

• 30095-47-7 2-bromo-1-(4-(tert-butyl)phenyl)ethanone 
• 116673-95-1 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole 

Downstream Products

• 156897-40-4 [2-(4-tert-Butyl-phenyl)-6,6-dimethyl-1-phenyl-6,7-dihydro-5H-pyrrolizin-3-yl]-acetic acid ethyl ester 
• 1175530-66-1 C₂₉H₃₅NO₂ 

Relevant articles and documents

Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX)

We synthesized and evaluated inhibitors for the microsomal prostaglandin E2 synthase-1 (mPGES-1), based on the arylpyrrolizine scaffold. In a cell free mPGES-1 assay several "sulfonimides" exceeded our leadML3000 (3) in potency. The most promising compound, the tolylsulfonimide 11f, revealed an IC50 of 2.1 μM and is equipotent to the literature reference molecule MK886 (1). Selected compounds also potently reduced 5-LOX product formation in intact cells. Inhibition of isolated COX was occasionally remarkably cut down.