1569316-51-3Relevant articles and documents
Hydrophilic anthracene fluorescent dye and synthesis method thereof
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Paragraph 0040; 0046-0049, (2021/02/10)
The invention provides a hydrophilic anthracene fluorescent dye and a synthesis method thereof. By introducing a sulfonic acid group and a difluoro substituent group, the hydrophilicity and stabilityof the anthracene fluorescent dye are improved. The synthesis method mainly comprises the following steps: reacting halogenated benzaldehyde with a phenyl Grignard reagent to generate a benzhydrol derivative; oxidizing an alcoholic hydroxyl group into a keto carbonyl group to obtain a benzophenone derivative with a phenolic hydroxyl group protecting group; converting the keto carbonyl group into dithioketal by using ethanedithiol for protection; carrying out fluorination by using a fluorine reagent to obtain an anthrone difluoride compound; conducting reacting by using a lithium reagent to achieve conversion into a lithium Grignard reagent; conducting oxidizing to obtain benzophenone; removing a protecting group from benzophenone, and carrying out cyclization reaction under an acidic condition; and carrying out sulfonation reaction on the obtained fluorinated fluorescent dye to obtain the fluorinated fluorescent dye.
Anthracene fluorescent dye synthesis and application
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, (2016/11/28)
The invention provides a novel fluorescent dye structure and a synthesis method thereof. The anthracene structure fluorescent dye of the type has a high light absorption coefficient similar to that of fluorescein molecules, a high quantum yield and the like and meanwhile has more bathochromic-shift excitation wavelength and emission wavelength. The synthesis method is simple and economical and suitable for large-scale synthesis and group modification of a molecular structure. According to the anthracene fluorescent dye synthesis and application, phosphatase substrate molecules with a fluorescent generation property can be obtained through phosphorylation modification conducted on the molecules, and wide biological application prospect is achieved.