156973-09-0

Basic information

• Product Name: 3-Pyridinemethanamine,6-amino-(9CI)
• Synonyms: 3-Pyridinemethanamine,6-amino-(9CI);6-AMINO-3-PYRIDINEMETHANAMINE;5-(Aminomethyl)pyridin-2-amine, (6-Aminopyridin-3-yl)methylamine;5-AMinoMethyl-pyridin-2-ylaMine;5-Aminomethyl-2-aminopyridine;6-Amino-3-(aminomethyl)pyridine
• CAS NO: 156973-09-0
• Molecular Formula: C₆H₉N₃
• Molecular Weight: 123.16
• Product Categories: PYRIDINE;pharmacetical
• Mol File: 156973-09-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 292.649 °C at 760 mmHg
• Flash Point: 155.793 °C
• Appearance: /
• Density: 1.174 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• PKA: 8.23±0.29(Predicted)
• CAS DataBase Reference: 3-Pyridinemethanamine,6-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinemethanamine,6-amino-(9CI)(156973-09-0)
• EPA Substance Registry System: 3-Pyridinemethanamine,6-amino-(9CI)(156973-09-0)

Safety Data

• Hazardous Substances Data: 156973-09-0(Hazardous Substances Data)

Usage

Description

3-Pyridinemethanamine,6-amino-(9CI), also known as 5-Aminomethyl-2-aminopyridine, is an organic compound with a pyridine ring structure and two amino groups. It is characterized by its unique chemical properties and potential applications in various fields.

Uses

Used in Pharmaceutical Research:
3-Pyridinemethanamine,6-amino-(9CI) is used as a reagent for studying aminopyridyl moiety-containing thrombin inhibitors. Its unique chemical structure allows it to interact with thrombin, a key enzyme in the blood clotting process, potentially leading to the development of novel anticoagulant drugs.
Used in Chemical Synthesis:
3-Pyridinemethanamine,6-amino-(9CI) can also be utilized as an intermediate in the synthesis of various pharmaceuticals and chemical products. Its versatile structure makes it a valuable building block for creating new molecules with specific properties and applications.

InChI:InChI=1/C6H9N3/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3,7H2,(H2,8,9)

Upstream product

• 4214-73-7 6-aminonicotinonitrile 
• 187237-37-2 2-(tert-butoxycarbonyl-amino)-5-aminomethylpyridine 
• 902837-44-9 tert-butyl (5-cyanopyridin-2-yl)carbamate 
• 329-89-5 6-aminonicotinic amide 

Downstream Products

• 183853-48-7 ((R)-1-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-diphenyl-ethyl)-carbamic acid tert-butyl ester 
• 183853-45-4 ((R)-1-{(S)-2-[(6-Amino-pyridin-3-ylmethyl)-carbamoyl]-pyrrolidine-1-carbonyl}-2,2-dicyclohexyl-ethyl)-carbamic acid tert-butyl ester 
• 1138321-45-5 6-{-4-[3-(6-Aminopyridin-3-ylmethyl)ureido]phenyl}-2-ethylamino-N-methylnicotinamide 
• 1180132-17-5 5-((4-ethylpiperazin-1-yl)methyl)-6-methylpyridin-2-amine 
• 1363130-82-8 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(benzenesulfonyl)phenyl]urea 

Relevant articles and documents

Pyridine methylamine compound and preparation method thereof

The invention provides a pyridine methylamine compound and a preparation method thereof. The preparation method comprises the steps that tetrahydrofuran and sodium borohydride are sequentially added into a cyanopyridine compound, then an iodine-containing tetrahydrofuran solution is dropwise added, a reaction is conducted at the temperature of 20-30 DEG C, and after dropwise adding is completed, stirring is carried out continuously; after the reaction is finished, methanol is added for refluxing, extracting and spin-drying are carried out to obtain the pyridine methylamine compound; wherein a functional group in the cyanopyridine compound is selected from chlorine, bromine, methyl, ethyl, amino or hydrogen; according to the preparation method, high-temperature and high-pressure special equipment does not need to be used, so that the preparation method is relatively safe, and dangerous accidents such as explosion and fire disasters are avoided; besides, the preparation method is relatively environment-friendly, recycling treatment of hazardous waste (used Raney nickel) is not involved, the economic benefit is relatively high, borane generated by the synthesis method is converted into boric acid esters in the post-treatment process, the treatment cost is low, and the harm to the environment is much small.

Method for preparing abemaciclib intermediate compound

The invention relates to a method for preparing an abemaciclib intermediate compound. The method comprises the following steps: fumaronitrile and nitromethane are subjected to condensation, hydrogenation cyclization is performed to obtain 2-amino-5-amino methylpyridine, and ring formation is performed on 2-amino-5-amino methylpyridine and N,N-bis(2-chloroethyl)ethylamine to prepare 5-(4-ethylpiperazine-1-yl)methyl-2-aminopyridine which can be used for preparing abemaciclib. Reagents with high price are not used, the atom economy is high, side reaction is less, the method is safe and high in product yield and purity, the raw materials are cheap and easily accessible, the operation is simple and convenient, and the cost is low.

NOVEL QUINOLINE DERIVATIVES

The invention relates to compounds represented by Formula (I): and to pharmaceutically acceptable salts or solvates of said compounds, wherein each of A, R3-8, X3, X5, m, and n are defined herein. The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula (I).