156994-73-9

Basic information

• Product Name: (R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
• Synonyms: (R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester
• CAS NO: 156994-73-9
• Molecular Weight: 366.414
• Mol File: 156994-73-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester(156994-73-9)
• EPA Substance Registry System: (R)-2-(3-Benzoyl-phenyl)-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester(156994-73-9)

Safety Data

• Hazardous Substances Data: 156994-73-9(Hazardous Substances Data)

Upstream product

• 22071-15-4 ketoprofen 
• 59512-44-6 ketoprofen chloride 
• 599-04-2 (R)-Pantolacton 

Downstream Products

• 56105-81-8 R-ketoprofen 

Relevant articles and documents

Asymmetric synthesis of ketoprofen: a surprising base catalyst effect during asymmetric addition of pantolactone to methyl (3-benzoylphenyl) ketene

The best diastereoselectivity of addition of a chiral alcohol to the ketene derived from ketoprofen was obtained with R or S pantolactone (ed=99percent).Depending on the tertiary amine used both for ketene formation and as catalyst during addition, the diastereoisomeric ratio of esters could be strongly modified and even inverted.Mild saponification afforded R or S ketoprofen in enantiomeric excess of up to 99percent.