1571113-58-0Relevant articles and documents
S-aroylthiooximes: A facile route to hydrogen sulfide releasing compounds with structure-dependent release kinetics
Foster, Jeffrey C.,Powell, Chadwick R.,Radzinski, Scott C.,Matson, John B.
, p. 1558 - 1561 (2014/04/17)
We report the facile preparation of a family of S-aroylthiooxime (SATO) H2S donors, which are synthesized via a click reaction analogous to oxime formation between S-aroylthiohydroxylamines (SATHAs) and aldehydes or ketones. Analysis of cysteine-triggered H2S release revealed structure-dependent release kinetics with half-lives from 8-82 min by substitution of the SATHA ring. The pseudo-first-order rate constants of substituted SATOs fit standard linear free energy relationships (p = 1.05), demonstrating a significant sensitivity to electronic effects.