1572383-53-9

Basic information

• Product Name: 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate
• Synonyms: 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate
• CAS NO: 1572383-53-9
• Molecular Weight: 379.459
• Mol File: 1572383-53-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate(1572383-53-9)
• EPA Substance Registry System: 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenyl propionate(1572383-53-9)

Safety Data

• Hazardous Substances Data: 1572383-53-9(Hazardous Substances Data)

Upstream product

• 24075-34-1 4-fluorophenyl isocyanide 
• 931-53-3 Cyclohexyl isocyanide 
• 1445-73-4 1-Methyl-4-piperidone 
• 95-55-6 2-amino-phenol 
• 1572383-01-7 2-(4-(benzo[d]oxazol-2-yl)-1-methylpiperidin-4-ylamino)phenol 
• 123-62-6 propionic acid anhydride 
• 1572383-23-3 4-methoxy-N-(1'-methylspiro[benzo[b][1,4]oxazine-3,4'-piperidine]-2(4H)-ylidene)aniline 

Relevant articles and documents

Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping

The formation of an unexpected heterocyclic scaffold, a benzoxazole, in a three-component reaction between a ketone, isocyanide, and 2-aminophenol was encountered. This reaction involved a benzo[b][1,4]oxazine intermediate resulting from intramolecular attack of the aminophenol hydroxyl group on the nitrilium ion. Unlike previous literature examples, the trapped nitrilium benzo[b][1,4]oxazine could readily be subjected to ring opening with bis-nucleophiles. The reaction scope includes simple linear as well as complex cyclic ketones and substituted 2-aminophenols. A representative benzoxazole product could be further diversified to yield drug-like compounds.