15732-75-9

Basic information

• Product Name: 3-benzoyl-2-methylenepropionic acid
• Synonyms: 3-benzoyl-2-methylenepropionic acid
• CAS NO: 15732-75-9
• Molecular Weight: 190.199
• Mol File: 15732-75-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 3-benzoyl-2-methylenepropionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzoyl-2-methylenepropionic acid(15732-75-9)
• EPA Substance Registry System: 3-benzoyl-2-methylenepropionic acid(15732-75-9)

Safety Data

• Hazardous Substances Data: 15732-75-9(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 7446-70-0 aluminium trichloride 
• 2170-03-8 itaconic acid anhydride 

Downstream Products

• 84143-17-9 (R)-2-methyl-4-oxo-4-phenylbutanoic acid 
• 84143-18-0 (S)-2-Methyl-4-oxo-4-phenylbutanoic acid 
• 36057-38-2 methyl (S)-2-methyl-4-oxo-4-phenylbutanoate 
• 80651-37-2 (R)-(-)-2-methyl-4-phenylbutyric acid 
• 130856-90-5 (3R,5S)-3-methyl-5-phenyl-4,5-dihydrofuran-2(3H)-one 
• 148903-67-7 β-benzoyl-2-methylenepropionic acid methyl ester 
• 130856-89-2 (3S,5S)-3-methyl-5-phenyl-4,5-dihydrofuran-2(3H)-one 
• 1771-65-9 2-methyl-4-oxo-4-phenylbutanoic acid 
• 1949-41-3 2-methyl-4-phenylbutanoic acid 
• 10606-64-1 3-methyl-5-phenyl-tetrahydrofuran-2-one 
• 36057-38-2 2-methyl-4-oxo-4-phenyl-butyric acid methyl ester 
• 13300-09-9 4-methyl-6-phenyl-2H-pyridazin-3-one 
• 15732-78-2 trans-2-Benzoyl-1-methyl-cyclopropan-⁽¹⁾-methylester 

Relevant articles and documents

Asymmetric Alkoxy- and Hydroxy-Carbonylations of Functionalized Alkenes Assisted by β-Carbonyl Groups

As a fundamental type of carbonylation reaction, the alkoxy- and hydroxy-carbonylation of unsaturated hydrocarbons constitutes one of the most important industrial applications of homogeneous catalysis. However, owing to the difficulties in controlling multi-selectivities for asymmetric hydrocarbonylation of alkenes, this reaction is typically limited to vinylarenes and analogues. In this work, a highly efficient asymmetric alkoxy- and hydroxy-carbonylation of β-carbonyl functionalized alkenes was developed, providing practical and easy access to various densely functionalized chiral molecules with high optical purity from broadly available alkenes, CO, and nucleophiles (>90 examples, 84–99 % ee). This protocol features mild reaction conditions and a broad substrate scope, and the products can be readily transformed into a diverse array of chiral heterocycles. Control experiments revealed the key role of the β-carbonyl group in determining the enantioselectivity and promoting the activity, which facilitates chiral induction by coordination to the transition metal as rationalized by DFT calculations. The strategy of utilizing an innate functional group as the directing group on the alkene substrate might find further applications in catalytic asymmetric hydrocarbonylation reactions.

Enzyme-Inspired Chiral Secondary-Phosphine-Oxide Ligand with Dual Noncovalent Interactions for Asymmetric Hydrogenation

Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary-phosphine-oxide) ligand (SPO-Wudaphos) which can enter into both ion pair and H-bond noncovalent interactions. The novel chiral SPO-Wudaphos exhibited excellent results

Synthesis and hypotensive activity of some 6-(substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones

6-(Substituted aryl)-4-methyl-2,3-dihydropyridazin-3-ones are synthesized by cyclisation of appropriate β-(substituted aroyl)-2-methylene propionate with hydrazine hydrate in the presence of sodium acetate. The title compounds are tested for hypotensive activity, non-invasively, by tail-cuff method and are found to possess significant hypotensive activity in normotensive rats.