157543-66-3

Basic information

• Product Name: (-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester
• Synonyms: (-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester
• CAS NO: 157543-66-3
• Molecular Weight: 628.997
• Mol File: 157543-66-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester(157543-66-3)
• EPA Substance Registry System: (-)-11α,15α-bis<(tert-butyldimethylsilyl)oxy>-9-oxo-16-phenoxy-17,18,19,20-tetranorprosta-4,15,13(t)-trienoic acid methyl ester(157543-66-3)

Safety Data

• Hazardous Substances Data: 157543-66-3(Hazardous Substances Data)

Upstream product

• 117253-98-2 (3S,4R)-3-(Methoxymethyloxy)-2-methylidene-4-(tert-butyldimethylsiloxy)cyclopentanone 
• 149862-37-3 (R)-3-<(tert-butyldimethylsilyl)oxy>-4-phenoxy-1-butyne 

Downstream Products

• 73121-56-9 (dl)-9-keto-11α,15α-dihydroxy-16-phenoxy-17,18,19,20-tetranorprosta-4,5,13-trans-trienoic acid methyl ester 

Relevant articles and documents

Synthesis of a Key Intermediate for Preparation of 4,5-Didehydro Prostaglandins containing an Allenyl Side-chain Group via Two-component Coupling Process. Synthesis of Enprostil

Enone 8, a key intermediate in the preparation of 4,5-didehydro prostaglandins via a two component coupling process, is prepared efficiently from readily available enone 6; the synthesis of enprostil, an antiulcer agent developed by Syntex, using enone 8 is also described.