1577180-41-6

Basic information

• Product Name: (3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone
• Synonyms: (3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone
• CAS NO: 1577180-41-6
• Molecular Weight: 493.791
• Mol File: 1577180-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone(1577180-41-6)
• EPA Substance Registry System: (3R,4S,5R)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-5-methoxycarbonyl-2-pyrrolidinone(1577180-41-6)

Safety Data

• Hazardous Substances Data: 1577180-41-6(Hazardous Substances Data)

Upstream product

• 1577180-45-0 (3R,4S,5S)-1-benzyl-5-cyano-3,4-diacetoxy-2-pyrrolidinone 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1577180-42-7 (2R,3S,4S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-2-methoxycarbonylpyrrolidine 
• 138258-69-2 (2R,3S,4S)-3,4-dihydroxyproline 
• 1577180-43-8 (2S,3S,4S)-1-benzyl-3,4-bis[(tert-butyldimethylsilyl)oxy]-2-hydroxymethylpyrrolidine 
• 1577468-54-2 1-benzyl-3,4-dihydroxyproline hydrochloride 
• 1577180-48-3 1-benzyl-3,4-dihydroxy-2-hydroxymethylpyrrolidine hydrochloride 

Relevant articles and documents

Stereoselective synthesis of 3,4-dihydroxylated prolines and prolinols starting from L -tartaric acid

A straightforward and stereoselective synthesis of 3,4-dihydroxyprolines and 3,4-dihydroxyprolinols is described. The key reaction in this synthesis is a protective group-controlled diastereoselective cyanation of a chiral acyliminium intermediate derived from l-tartaric acid. Methanolysis of the obtained cyanolactam gave methyl 3,4-dihydroxypyroglutamate that was converted to 3,4-dihydroxyproline and 3,4-dihydroxyprolinol by reduction of the lactam carbonyl and ester groups in a stepwise manner.