1577210-89-9

Basic information

• Product Name: (3-(difluoromethoxy)propyl) benzene
• Synonyms: (3-(difluoromethoxy)propyl) benzene
• CAS NO: 1577210-89-9
• Molecular Weight: 186.201
• Mol File: 1577210-89-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (3-(difluoromethoxy)propyl) benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(difluoromethoxy)propyl) benzene(1577210-89-9)
• EPA Substance Registry System: (3-(difluoromethoxy)propyl) benzene(1577210-89-9)

Safety Data

• Hazardous Substances Data: 1577210-89-9(Hazardous Substances Data)

Upstream product

• 122-97-4 3-Phenyl-1-propanol 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 1493-03-4 iododifluoromethane 
• 75-45-6 Chlorodifluoromethane 
• 104-64-3 3-phenyl-1-propanol formate ester 
• 4620-66-0 γ-Phenylpropyl-dichlormethylether 

Relevant articles and documents

Direct Difluoromethylation of Alcohols with an Electrophilic Difluoromethylated Sulfonium Ylide

A general method for the formation of alkyl difluoromethylethers under mild reaction conditions and with good functional-group tolerance was developed. The development of the method was based on the invention of a stable, electrophilic, difluoromethylating reagent, difluoromethyl-(4-nitrophenyl)-bis(carbomethoxy) methylide sulfonium ylide, which was synthesized by reaction of the easily available 4-nitrophenyl (difluoromethyl)thioether and dimethyl diazomalonate in the presence of a rhodium catalyst.

Difluoromethylation of alcohols with TMSCF2Br in water: A new insight into the generation and reactions of difluorocarbene in a two-phase system

Although many difluorocarbene-involved reactions can be performed in the presence of water, the reaction of difluorocarbene using water as the only reaction medium is rare. By using TMSCF2Br as a unique difluorocarbene reagent and KHF2 as a mild activator, the difluoromethylation of liquid alcohols in water is described. This research not only develops an environmentally benign process for the synthesis of difluoromethyl ethers, but also provides a new insight into the generation and reactions of difluorocarbene in an oil-water two-phase system.

Synthetic method for alkyl difluoromethyl ether compound

The invention discloses a synthetic method for an alkyl difluoromethyl ether compound with convenience, high efficiency, mild conditions, high universality and high operability, and having the advantage of conveniently constructing a difluoromethoxy structure (OCF2H) in the later stage of total synthesis of target molecules. The synthetic method for the alkyl difluoromethyl ether compound is characterized by comprising a difluoromethyl etherification reaction of fatty alcohols and a difluoromethyl etherification reaction of mercaptan: the reagent used in the difluoromethyl etherification reaction of the fatty alcohols is as shown in the formula or an analogue of the formula; and the reagent used in the difluoromethyl etherification reaction of mercaptan is as shown in the formula or an analogue of the formula.