157722-43-5Relevant articles and documents
Application of Yeast-Catalyzed Reductions to Synthesis of (2R,3S)-Phenylisoserine
Kearns, Jeff,Kayser, Margaret
, p. 2845 - 2848 (2007/10/02)
A simple synthesis of (2R,3S)-phenylisoserine, a precursor of the C-13 side chain of Taxol (paclitaxel), utilising yeast-catalyzed reduction to generate a second chiral centre is reported.This short enantioselective series of transformations can be readily adapted to large scale production of a variety of N-substituted paclitaxel analogues.