157729-42-5

Basic information

• Product Name: 1-(5-O-(tert-butyldiphenylsilyl)-2′-deoxy-β-D-erythro-pentofuranosyl)-N²-isobutyrylguanine
• Synonyms: 1-(5-O-(tert-butyldiphenylsilyl)-2′-deoxy-β-D-erythro-pentofuranosyl)-N²-isobutyrylguanine
• CAS NO: 157729-42-5
• Molecular Weight: 575.74
• Mol File: 157729-42-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-O-(tert-butyldiphenylsilyl)-2′-deoxy-β-D-erythro-pentofuranosyl)-N²-isobutyrylguanine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-O-(tert-butyldiphenylsilyl)-2′-deoxy-β-D-erythro-pentofuranosyl)-N²-isobutyrylguanine(157729-42-5)
• EPA Substance Registry System: 1-(5-O-(tert-butyldiphenylsilyl)-2′-deoxy-β-D-erythro-pentofuranosyl)-N²-isobutyrylguanine(157729-42-5)

Safety Data

• Hazardous Substances Data: 157729-42-5(Hazardous Substances Data)

Upstream product

• 68892-42-2 N-isobutyryl-2'-deoxyguanosine 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 157729-46-9 N-{9-[(2R,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-((E)-styryl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-isobutyramide 
• 157729-44-7 Thiocarbonic acid O-[(2R,3S,5R)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl] ester O-phenyl ester 

Relevant articles and documents

An easy access of 2',3'-dideoxy-3'-α-C-formyl-adenosine and -guanosine analogs via stereoselective C-C bond forming radical reaction

A large-scale, facile and stereoselective synthesis of 1-[5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-α-C-formyl-β-D-erythr o-pentofuranosyl] -adenine (7b) and -N2-isobutyrylguanine (7c) using an intermolecular radical C-C bond formation reaction is reported. The utility of these nucleosides (7b and 7c) as building blocks for antisense oligonucleosides is discussed.