157731-85-6

Basic information

• Product Name: (6S,7S)-3-Bromomethyl-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• Synonyms: (6S,7S)-3-Bromomethyl-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS NO: 157731-85-6
• Molecular Weight: 589.466
• Mol File: 157731-85-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6S,7S)-3-Bromomethyl-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6S,7S)-3-Bromomethyl-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(157731-85-6)
• EPA Substance Registry System: (6S,7S)-3-Bromomethyl-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester(157731-85-6)

Safety Data

• Hazardous Substances Data: 157731-85-6(Hazardous Substances Data)

Upstream product

• 136248-53-8 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-methyl-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Downstream Products

• 187544-47-4 C₇₁H₅₉N₉O₉S₃ 
• 136248-41-4 (6S,7S)-7-{2-[(Z)-2,2-Dimethyl-benzo[1,3]dioxol-5-ylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-61-8 (6S,7S)-3-(1-Benzhydryloxycarbonylmethyl-1H-tetrazol-5-ylsulfanylmethyl)-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-59-4 (6S,7S)-3-(5-Benzhydryloxycarbonylmethyl-4-methyl-thiazol-2-ylsulfanylmethyl)-7-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 138686-36-9 (6S,7S)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-tert-butoxycarbonyl-1-methyl-ethoxyimino]-acetylamino}-8-oxo-3-(pyridin-4-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-38-9 (6S,7S)-7-{2-[(Z)-1,5-Bis-benzhydryloxy-4-oxo-1,4-dihydro-pyridin-2-ylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-([1,3,4]thiadiazol-2-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-40-3 (6S,7S)-7-{2-[(Z)-1,5-Bis-benzhydryloxy-4-oxo-1,4-dihydro-pyridin-2-ylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-([1,2,3]thiadiazol-5-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 187544-45-2 (6S,7S)-7-{2-[(Z)-1,5-Bis-benzhydryloxy-4-oxo-1,4-dihydro-pyridin-2-ylmethoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-3-(pyridin-4-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-51-6 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-(5-methyl-[1,3,4]thiadiazol-2-ylsulfanylmethyl)-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-52-7 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-3-([1,3,4]thiadiazol-2-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136278-83-6 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-[1-(2-hydroxy-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 136248-57-2 (6S,7S)-7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-8-oxo-3-(pyridin-4-ylsulfanylmethyl)-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 

Relevant articles and documents

Synthesis and Structure-Activity relationships of cephalosporins, 2-isocephems, and 2-oxaisocephems with C-3' or C-7 catechol or related aromatics

A series of cephalosporins, 2-isocephems, and 2-oxaisocephems with C-3' catechol-containing (pyridinium-4-thio)methyl groups and 2-isocephems with C-7 catechol related aromatics have been prepared and evaluated for antimicrobial activity. It turns out that these compounds have highly potent activity against Gram-negative bacteria, especially resistant pathogens such as Pseudomonas aeruginosa. The most active compound of the series was (6S,7S)-7-[2-(2-aminothiazol-4-yl)-2-[(Z)-[(1,5-dihydroxy- 4-pyridon-2-yl)methoxy]imino]acetamido]-3-[[[(4-methyl-5- carboxymethyl)thiazol-2-yl]thio] methyl]-8-oxo-1-aza-4-thiabicyclo [4.2.0]-aza-4-thiabicyclo [4.2.0] oct-2-ene-2-carboxylic acid which exhibited potent in vitro activity against clinically isolated P. aeruginosa and Acinetobacter baumanii which is also resistant to many anti-infectives, and good in vivo efficacy against clinically isolated P aeruginosa.