15777-70-5

Basic information

• Product Name: 4-hydroxy-3-methylbenzonitrile
• Synonyms: 4-hydroxy-3-methylbenzonitrile;2-Methyl-4-cyanophenol
• CAS NO: 15777-70-5
• Molecular Formula: C₈H₇NO
• Molecular Weight: 133.14728
• Mol File: 15777-70-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-hydroxy-3-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-3-methylbenzonitrile(15777-70-5)
• EPA Substance Registry System: 4-hydroxy-3-methylbenzonitrile(15777-70-5)

Safety Data

• Hazardous Substances Data: 15777-70-5(Hazardous Substances Data)

Usage

General Description

4-hydroxy-3-methylbenzonitrile, also known as p-cresol, is a chemical compound that belongs to the phenols and phenolics class of compounds. It is a colorless to pale yellow liquid and has a characteristic phenolic odor. It is commonly used as an intermediate in the production of various chemical compounds including antioxidants, pharmaceuticals, and fragrances. p-cresol is also found in coal tar, tobacco smoke, and as a metabolite of certain bacteria in the human body. It is considered to be toxic if ingested or inhaled in large quantities, and exposure to the compound can cause irritation to the skin, eyes, and respiratory tract. Additionally, prolonged exposure to p-cresol has been linked to potential health hazards including nephrotoxicity and neurotoxicity.

Upstream product

• 2362-12-1 4-Bromo-2-methylphenol 
• 499-76-3 4-hydroxy-3-methylbenzoic acid 
• 848953-05-9 3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 95-48-7 ortho-cresol 
• 53078-71-0 4-methoxy-3-methylbenzonitrile 
• 352616-29-6 3-methyl-4-t-butyloxy-benzonitrile 
• 13589-71-4 3-methylhydroxy-benzonitrile 
• 15174-69-3 4-hydroxy-3-methyl-benzaldehyde 
• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 78881-21-7 4-amino-3-methylbenzonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 553-97-9 2-Methyl-1,4-benzoquinone 
• 103264-03-5 4-acetoxy-3-methyl-benzonitrile 

Downstream Products

• 108839-34-5 3,3'-dimethyl-4,4'-but-2-ynediyldioxy-di-benzonitrile 
• 186552-02-3 (4-cyano-2-methylphenoxy)acetic acid methyl ester 
• 173900-31-7 3-Methyl-4-[3-(3-methylisoxazol-5yl)propyloxy]phenylcyanide 
• 1608146-24-2 N-hydroxy-3-iodo-4-isopropoxy-5-methylbenzimidamide 
• 1608146-28-6 3-iodo-4-isopropoxy-5-methylbenzonitrile 
• 1608148-61-3 C₈H₆INO 
• 475651-47-9 4-(5-ethyl-1,2,4-oxadiazol-3-yl)-2-methylphenol 

Relevant articles and documents

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses

Today, there are no medicines to treat enterovirus and rhinovirus infections. In the present study, a series of novel pleconaril derivatives with substitutions in the isoxazole and phenyl rings was synthesized and evaluated for their antiviral activity against a panel of pleconaril-sensitive and -resistant enteroviruses. Studies of the structure-activity relationship demonstrate the crucial role of the N,N-dimethylcarbamoyl group in the isoxazole ring for antiviral activity against pleconaril-resistant viruses. In addition, one or two substituents in the phenyl ring directly impact on the spectrum of antienteroviral activity. The 3-(3-methyl-4-(3-(3-N,N-dimethylcarbamoyl-isoxazol-5-yl)propoxy)phenyl)-5-trifluoromethyl-1,2,4-oxadiazole 10g was among the compounds exhibiting the strongest activity against pleconaril-resistant as well as pleconaril-susceptible enteroviruses with IC50 values from 0.02 to 5.25 μM in this series. Compound 10g demonstrated markedly less CYP3A4 induction than pleconaril, was non-mutagenic, and was bioavailable after intragastric administration in mice. These results highlight compound 10g as a promising potential candidate as a broad spectrum enterovirus and rhinovirus inhibitor for further preclinical investigations.

Visible-Light Photoredox Borylation of Aryl Halides and Subsequent Aerobic Oxidative Hydroxylation

Efficient and practical visible-light photoredox borylation of aryl halides and subsequent aerobic oxidative hydroxylation were developed. The protocols use readily available aryl halides and bis(pinacolato)diboron as the starting materials, fac-Ir(ppy)3 as the photocatalyst, and corresponding arylboronic esters and phenols were obtained in good yields. The methods show some advantages including simple equipment, mild conditions, easy operation, and wide substrate scope. Therefore, they should provide a valuable strategy for chemical transformations.

IMIDAZOLIDINEDIONE DERIVATIVES

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.