15783-48-9

Basic information

• Product Name: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one
• Synonyms: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one;2,4-Dichlorofuro[3,4-d]pyrimidin-7(5H)-one
• CAS NO: 15783-48-9
• Molecular Formula: C₆H₂Cl₂N₂O₂
• Molecular Weight: 168.10696
• EINECS: -0
• Mol File: 15783-48-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 464.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.760±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -5.44±0.20(Predicted)
• CAS DataBase Reference: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one(15783-48-9)
• EPA Substance Registry System: 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one(15783-48-9)

Safety Data

• Hazardous Substances Data: 15783-48-9(Hazardous Substances Data)

Usage

General Description

2,4-dihydroxyfuro[3,4-d]pyrimidin-7(5H)-one is a chemical compound with a unique fused ring structure that belongs to the class of pyrimidine derivatives. It is also known as uracil glycol and is an intermediate in the biosynthesis of riboflavin. 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one has been studied for its potential biological activity, including its role in the formation of DNA cross-links, which can lead to cytotoxicity in cancer cells. Additionally, 2,4-dihydroxyfuro[3,4-d]pyrimidin-7(5H)-one has been investigated for its potential as an inhibitor of the enzyme dihydrouracil dehydrogenase, which is involved in the metabolism of the anticancer drug 5-fluorouracil. 2,4-dihydroxyfuro[3,4-d]pyriMidin-7(5H)-one holds promise for further research in the development of new pharmaceuticals and bioactive molecules.

Upstream product

• 4156-75-6 2,4-dihydroxyfuro[3,4-d]pyrimidin-7(5H)-one 
• 4156-75-6 furo<3,4-d>pyrimidine-2,4,7(1H,3H,5H)-trione 

Downstream Products

• 15783-56-9 2-chloro-4-(phenylamino)furo[3,4-d]pyrimidin-7(5H)-one 
• 1262443-61-7 1-(4-(4'-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-5'H-spiro[cyclopropane-1,7'-furo[3,4-d]pyrimidine]-2'-yl)phenyl)-3-methylurea 
• 1262443-60-6 1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-7-hydroxy-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidin-2-yl)phenyl)-3-methylurea 
• 1079655-16-5 4-(benzhydryl-amino)-2-[4-(2-dimethylamino-acetyl)-piperazin-1-yl]-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079655-01-8 2-{4-[4-(benzhydryl-amino)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-piperazin-1-yl}-N,N-dimethyl-acetamide 
• 1079655-05-2 4-(benzhydryl-amino)-6-isopropyl-2-(4-methanesulfonyl-piperazin-1-yl)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079654-72-0 2-(4-acetyl-piperazin-1-yl)-4-(benzhydryl-amino)-6-isopropyl-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079654-87-7 C₂₇H₃₂N₆O 
• 1079654-92-4 4-(benzhydryl-amino)-6-isopropyl-2-(2-methoxy-ethylamino)-5,6-dihydro-pyrrolo[3,4-d]pyrimidin-7-one 
• 1079655-11-0 N-{1-[4-(benzhydryl-amino)-6-isopropyl-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl]-pyrrolidin-3-yl}-acetamide 
• 1080064-69-2 C₂₆H₃₀N₆O 

Relevant articles and documents

Probing the Reactivity of 2,4-Dichlorofuro[3,4-d ]pyrimidin-7-one: A Versatile and Underexploited Scaffold to Generate Substituted or Fused Pyrimidine Derivatives

Herein, we describe the results of our investigation on the chemical reactivity and versatility of a poorly explored scaffold: 2,4-dichlorofuro[3,4-d ]pyrimidin-7-one (3). Highly functionalized pyrimidines can be obtained with a divergent approach by reacting the key intermediate 3 with different amine nucleophiles under carefully controlled reaction conditions. The set-up of a microwave-Assisted one-pot, two-or three-step protocol to rapidly generate 2,4,5,6-Tetrasubstituted or fused pyrimidines is also reported.

DIHYDROFUROPYRIMID1NE COMPOUNDS

The present invention provides mTOR inhibitors of the formula (I) wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods of making the compounds and intermediates thereof; and methods of using the compounds.

OXO-HETEROCYCLE FUSED PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).