1578300-80-7

Basic information

• Product Name: 7-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butoxy)-2,3-dihydro-cyclopenta[c]chromen-4(1H)-one
• Synonyms: 7-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butoxy)-2,3-dihydro-cyclopenta[c]chromen-4(1H)-one
• CAS NO: 1578300-80-7
• Molecular Weight: 486.534
• Mol File: 1578300-80-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butoxy)-2,3-dihydro-cyclopenta[c]chromen-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butoxy)-2,3-dihydro-cyclopenta[c]chromen-4(1H)-one(1578300-80-7)
• EPA Substance Registry System: 7-(4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)butoxy)-2,3-dihydro-cyclopenta[c]chromen-4(1H)-one(1578300-80-7)

Safety Data

• Hazardous Substances Data: 1578300-80-7(Hazardous Substances Data)

Upstream product

• 21260-41-3 7-hydroxy-2,3-dihydrocyclopenta[c]chromen-4(1H)-one 
• 1578300-93-2 7-(4-bromobutoxy)-2,3-dihydrocyclopenta[c]chromen-4(1H)-one 
• 15532-75-9 1-(3-Trifluoromethylphenyl)piperazine 
• 627-93-0 hexanedioic acid dimethyl ester 
• 124-04-9 Adipic acid 

Relevant articles and documents

Synthesis and evaluation of new coumarin derivatives as potential atypical antipsychotics

In this paper, we report the synthesis of novel, potential antipsychotic coumarin derivatives combining potent dopamine D2, D3 and serotonin 5-HT1A, 5-HT2A receptors properties. We describe the structure activity relationship that leads us to the promising derivative: 7-(4-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)butoxy)-6-methyl-2, 3-dihydrocyclopenta[c]chromen-4(1H)-one 27. The unique pharmacological features of compound 27 are a high affinity for dopamine D2, D3 and serotonin 5-HT1A, 5-HT2A receptors, together with a low affinity for H1 receptor (to reduce the risk of obesity under chronic treatment). In animal models, compound 27 inhibited apomorphine-induced climbing and MK-801-induced hyperactivity without observable catalepsy at the highest dose tested. In particular, compound 27 was more potent than clozapine.