15785-54-3

Basic information

• Product Name: 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID
• Synonyms: 3-Nitro-4-hydroxy-5-methoxybenzoic acid;5-Nitrovanillic acid
• CAS NO: 15785-54-3
• Molecular Formula: C₈H₇NO₆
• Molecular Weight: 213.15
• Mol File: 15785-54-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 216℃
• Boiling Point: 386℃
• Flash Point: 187℃
• Appearance: /
• Density: 1.564
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.82±0.10(Predicted)
• CAS DataBase Reference: 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID(15785-54-3)
• EPA Substance Registry System: 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID(15785-54-3)

Safety Data

• Hazardous Substances Data: 15785-54-3(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID is a chemical compound that belongs to the family of benzoic acids and is commonly used in the pharmaceutical and cosmetic industries. It is a nitrobenzoic acid derivative with a hydroxy and methoxy group attached to the benzene ring. 4-HYDROXY-3-METHOXY-5-NITROBENZOIC ACID has been studied for its potential biological activities including its anti-inflammatory, antioxidative, and antimicrobial properties. It is also used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. Additionally, it is used as a dye intermediate and as a component in sunscreen formulations.

Upstream product

• 6635-20-7 isonitrovanillin 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 
• 832677-12-0 4-acetoxy-3-methoxy-5-nitro-benzonitrile 
• 7782-77-6 cis-nitrous acid 
• 7697-37-2 nitric acid 
• 121-33-5 vanillin 
• 56521-01-8 4-allyl-2-methoxy-6-nitrophenol 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 64-19-7 acetic acid 
• 56-23-5 tetrachloromethane 
• 7732-18-5 water 
• 42590-00-1 4-hydroxy-3-methoxy-5-nitrobenzoic acid methyl ester 
• 91004-48-7 4,5-Dimethoxy-3-nitrobenzoic acid 
• 62-53-3 aniline 

Downstream Products

• 84211-30-3 3,4-dihydroxy-5-nitrobenzoic acid 
• 3934-84-7 3,4-dihydroxy-5-methoxybenzoic acid 
• 1402714-41-3 5-[3-(2,5-dichloro-4,6-dimethyl-1-oxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene 
• 923287-50-7 2,5-dichloro-3-(5-(3,4-dihydroxy-5-nitrophenyl)-1,2,4-oxadiazol-3-yl)-4,6-dimethylpyridine 1-oxide 
• 1391712-50-7 5-[3-(2,5-dichloro-4,6-dimethyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-2-hydroxy-3-methoxy-1-nitrobenzene 
• 15785-53-2 3-amino-4-hydroxy-5-methoxybenzoic acid hydrochloride 
• 163495-29-2 3-(6-Acetoxymethyl-6-methoxymethoxy-3,6-dihydro-[1,2]oxazin-2-yl)-5-benzyloxy-4-iodo-benzoic acid methyl ester 
• 163495-28-1 3-Benzyloxy-5-(6-hydroxymethyl-6-methoxymethoxy-3,6-dihydro-[1,2]oxazin-2-yl)-4-iodo-benzoic acid methyl ester 
• 438547-22-9 3-Benzyloxy-5-nitro-4-trifluoromethanesulfonyloxy-benzoic acid methyl ester 

Relevant articles and documents

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CHEMICAL COMPOUND USEFUL AS INTERMEDIATE FOR PREPARING A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

There is disclosed a methylated intermediate which may be demethylated to provide an inhibitor of catechol-O-methyltransferase useful in the treatment of Parkinson's disease. Also disclosed are methods of making and using said intermediate.

Oxadiazole derivatives as COMT inhibitors

This invention relates to novel substituted [1,2,4]-oxadiazoles, their use in the treatment of some central and peripheral nervous system disorders, methods for their preparation and pharmaceutical compositions containing them.