157911-56-3 Usage
Description
2,4,5-Trifluorobenzyl bromide is a white low melting solid that serves as a useful research chemical in various scientific and industrial applications.
Uses
Used in Research and Development:
2,4,5-Trifluorobenzyl bromide is used as a research chemical for the development and synthesis of new compounds and materials. Its unique properties make it a valuable tool in the exploration of novel chemical reactions and the creation of innovative products.
Used in Pharmaceutical Industry:
2,4,5-Trifluorobenzyl bromide is used as an intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and structural features contribute to the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
2,4,5-Trifluorobenzyl bromide is used as a building block in the synthesis of complex organic molecules. Its trifluoromethyl groups provide unique reactivity and selectivity, making it a valuable component in the creation of advanced materials and specialty chemicals.
Used in Material Science:
2,4,5-Trifluorobenzyl bromide is used as a component in the development of new materials with specific properties, such as improved thermal stability, chemical resistance, or electronic characteristics. Its incorporation into polymers and other materials can enhance their performance and expand their potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 157911-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,7,9,1 and 1 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 157911-56:
(8*1)+(7*5)+(6*7)+(5*9)+(4*1)+(3*1)+(2*5)+(1*6)=153
153 % 10 = 3
So 157911-56-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H4BrF3/c8-3-4-1-6(10)7(11)2-5(4)9/h1-2H,3H2
157911-56-3Relevant articles and documents
Biocatalytic retrosynthesis approaches to d-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin
Parmeggiani, Fabio,Rué Casamajo, Arnau,Colombo, Danilo,Ghezzi, Maria Chiara,Galman, James L.,Chica, Roberto A.,Brenna, Elisabetta,Turner, Nicholas J.
, p. 4368 - 4379 (2019/08/21)
The integration of biocatalytic steps in retrosynthetic analysis of a target molecule offers multiple advantages, such as reduction of the environmental footprint of the process, viability of milder and safer reaction conditions, and accessibility of transformations that are challenging with traditional chemical synthesis. Herein, six chemo-enzymatic routes are described for the synthesis of a fluorinated d-phenylalanine derivative, precursor of the blockbuster antidiabetic drug sitagliptin. All routes start from the same aldehyde precursor and involve at least one biocatalytic step, including reductive amination, transamination, deracemisation, hydroamination, and alkene reduction. The target molecule was obtained in 2-5 steps from the aldehyde, with ee up to >99% and in 36-62% isolated yield. Furthermore, as part of one of the routes, the first example of a fully biocatalytic conversion of a cinnamic acid derivative to the corresponding d-phenylalanine (formal d-selective hydroamination) is reported.