15795-39-8Relevant articles and documents
Synthesis method of 2-methyl-1, 2, 4-triazole-3-amine
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Paragraph 0007; 0009, (2020/09/16)
The invention relates to a synthesis method of 2-methyl-1, 2, 4-triazole-3-amine, and mainly solves the technical problem that no suitable industrial synthesis method exists at present. The method comprises the following three steps: 1, reacting a compound 1 in a solvent 1, 4-dioxane with added N, N-dimethylformamide dimethyl acetal to obtain a compound 2; 2, reacting the compound 2 with triphenylphosphine and diisopropyl azodicarboxylate in methanol to obtain a compound 3; and 3, reacting the compound 3 with sodium hydroxide in methanol and water to obtain a final compound 4, wherein the reaction formula is described in the specification.
Synthesis of 1-Alkyl-5-amino-1,2,4-triazoles Based on Nucleophilic Substitution and Reduction Reactions
Tolstyakov
, p. 1537 - 1547 (2019/01/04)
A series of 1-alkyl-5-amino-1H-1,2,4-triazoles were synthesized starting from 3,5-dibromo-1H- 1,2,4-triazole by alkylation and subsequent nucleophilic substitution of the 5-bromine atom by azido group, reduction of the latter to amino group, and hydrodebromination.
Development of a scaleable process for the synthesis of a next-generation statin
Hobson, Lindsay A.,Akiti, Otute,Deshmukh, Subodh S.,Harper, Shannon,Katipally, Kishta,Lai, Chiajen J.,Livingston, Robert C.,Lo, Ehrlic,Miller, Michael M.,Ramakrishnan, Srividya,Shen, Lifen,Spink, Jan,Tummala, Srinivas,Wei, Chenkou,Yamamoto, Kana,Young, John,Parsons Jr., Rodney L.
scheme or table, p. 441 - 458 (2011/04/22)
This manuscript details the process research and development of a convergent and safe approach to 1 on a multikilo scale. Specific highlights of the process development efforts will be described, including the development of a dehydrogenation method for d