1580002-52-3Relevant articles and documents
Activity of caffeic acid derivatives against Candida albicans biofilm
De Vita, Daniela,Friggeri, Laura,D'Auria, Felicia Diodata,Pandolfi, Fabiana,Piccoli, Francesco,Panella, Simona,Palamara, Anna Teresa,Simonetti, Giovanna,Scipione, Luigi,Di Santo, Roberto,Costi, Roberta,Tortorella, Silvano
, p. 1502 - 1505 (2014)
The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16 μg/mL, respectively, and in the early stage of biofilm formation (4 h) with MIC 50 values of 64, 32 and 64 μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24 h), especially 8 and 10 with MIC50 values of 64 μg/mL.