1580482-83-2Relevant articles and documents
Multicomponent synthesis of bicyclic thiazolidinethiones and oxazolidinones in water
Stalling, Timo,Pauly, Jan,Schmidtmann, Marc,Martens, Juergen
, p. 833 - 843 (2014/03/21)
A powerful three-component reaction for the synthesis of bicyclic thiazolidinethiones and oxazolidinones at room temp. in water, starting from readily available amines, chloroacetaldehyde, and CS2/CO2, is described. A simple one-pot pro-cedure allows the construction of two new cyclic systems and four new bonds, with all reactants being efficiently utilized in this transformation. KHCO3 is used as a productive source of CO2. Broad potential for derivatization is demonstrated.