15811-21-9

Basic information

• Product Name: SPIRO[2.5]OCTAN-6-ONE
• Synonyms: SPIRO[2.5]OCTAN-6-ONE;8-methylidene-1,4-dioxaspiro[4.5]decane
• CAS NO: 15811-21-9
• Molecular Formula: C₈H₁₂O
• Molecular Weight: 124.18
• Mol File: 15811-21-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 194.2±8.0 °C(Predicted)
• Appearance: /
• Density: 1.02±0.1 g/cm3(Predicted)
• CAS DataBase Reference: SPIRO[2.5]OCTAN-6-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: SPIRO[2.5]OCTAN-6-ONE(15811-21-9)
• EPA Substance Registry System: SPIRO[2.5]OCTAN-6-ONE(15811-21-9)

Safety Data

• Hazardous Substances Data: 15811-21-9(Hazardous Substances Data)

Usage

Description

Spiro[2.5]octan-6-one is a unique organic compound characterized by its spiro ring structure and a ketone functional group. It is known for its potential applications in various fields due to its distinct chemical properties.

Uses

Used in Pharmaceutical Industry:
Spiro[2.5]octan-6-one is used as a P2X3 inhibitor for treating P2X3 receptor dysfunction diseases. P2X3 receptors are ion channels found in sensory neurons, and their dysfunction has been associated with various pain-related conditions. By inhibiting these receptors, Spiro[2.5]octan-6-one can help alleviate pain and improve the quality of life for patients suffering from such diseases.

Upstream product

• 51656-90-7 8-methylene-1,4-dioxaspiro[4.5]decane 
• 1354932-10-7 9-methylene-1,5-dioxaspiro[5.5]undecane 
• 52875-47-5 7,10-dioxadispiro[2.2.4⁶.2³]dodecane 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 185-65-9 spiro[2.5]octane 
• 75-11-6 diiodomethane 

Downstream Products

• 1424996-19-9 C₂₉H₃₂N₂O₅S 
• 1424995-28-7 C₁₅H₁₆N₂O₃ 
• 1424995-31-2 C₂₄H₂₃NO₄ 
• 1424995-32-3 C₂₅H₂₅NO₄ 
• 99799-73-2 spiro[2.5]octane-6-amine 
• 1557232-34-4 N-(1-benzyl-1H-pyrazol-4-yl)-1',4',5',7'-tetrahydrospiro[cyclopropane-1,6'-indazole]-3'-carboxamide 
• 1557248-89-1 C₂₆H₃₅N₅O₂Si 
• 1516885-76-9 (S)-N-(3-(2-ethyl-4-(5-(3-ethyl-6,7-dihydro-4H-spiro[benzo[c]thiophene-5,1'-cyclopropan]-1-yl)-1,2,4-oxadiazol-3-yl)-6-methylphenoxy)-2-hydroxypropyl)-2-hydroxyacetamide 
• 910636-73-6 C₂₃H₂₆O₂S 

Relevant articles and documents

PYRROLO[2,3-C]PYRIDINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE

Disclosed are a pyrrolo[2,3-c]pyridine derivative, a preparation method therefor, and use thereof in medicine. Specifically, disclosed are a pyrrolo[2,3-c]pyridine derivative as represented by general formula (1), a preparation method therefor, a pharmaceutical composition comprising the derivative, as well as use thereof as a BRD4 inhibitor in the treatment of related diseases such as cancers, inflammations, chronic liver diseases, diabetes, cardiovascular diseases and AIDS, each substituent in general formula (I) being same as defined in the description.

CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Compounds of formula I are provided, which are JAK inhibitors and are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.