1581266-93-4

Basic information

• Product Name: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate
• Synonyms: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate
• CAS NO: 1581266-93-4
• Molecular Weight: 683.933
• Mol File: 1581266-93-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate(1581266-93-4)
• EPA Substance Registry System: methyl (R)-2-{(S,E)-3-[(4-methoxybenzyl)oxy]-7-(tritylthio)hept-4-enamido}-4-(methylthio)butanoate(1581266-93-4)

Safety Data

• Hazardous Substances Data: 1581266-93-4(Hazardous Substances Data)

Upstream product

• 1027785-31-4 (S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoic acid 
• 69630-60-0 methyl D-methioninate hydrochloride 
• 21691-49-6 D-methionine methyl ester 

Downstream Products

• 1581266-95-6 (R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enamide]-4-(methylthio)butanoic acid 
• 1581266-97-8 (3S,4R)-allyl 3-(tert-butyldimethylsiloxy)-4-{(S)-2-[(R)-2-[(S,E)-3-(4-methoxybenzyloxy)-7-(tritylthio)hept-4-enoylamino]-4-(methylthio)butanoylamino]-3-tritylthio(propionylamino)}-5-methylhexanoate 
• 1581267-11-9 (2S,6R,9S,12R,13S)-12-[(S)-isobutyl]-13-(tert-butyldimethylsilyloxy)-6-[2-(methylthio)ethyl]-2-[(E)-4-(tritylthio)but-1-en-1-yl]-9-tritylthiomethyl-1-oxa-5,8,11-triazacyclopentadecane-4,7,10,15-tetraone 

Relevant articles and documents

A Concise Approach for Producing Optically Pure Carboxylic Acid Segments for the Synthesis of Bicyclic Depsipeptide Histone Deacetylase Inhibitors

Optically pure carboxylic acid segments, which are common key intermediates for the synthesis of naturally occurring bicyclic depsipeptide histone deacetylase inhibitors, have been produced efficiently. The method features the chromatographic separation of two diastereomers, which were formed by direct amide condensation of racemic (3 RS,4 E)-3-hydroxy-7-mercaptohept-4-enoic acid (rac -Hmh) with chiral amino acids. This approach offers a reliable and practical method for producing optically pure carboxylic acid segments, which can facilitate easier access to important anticancer agents derived from them.