158143-60-3Relevant articles and documents
Halogenated 2-amino-4H-benzo[h]chromene derivatives as antitumor agents and the relationship between lipophilicity and antitumor activity
El-Agrody, Ahmed M.,Fouda, Ahmed M.,Khattab, Essam Shawky A. E. H.
, p. 691 - 700 (2017)
Several halogenated 2-amino-4H-benzo[h]chromene derivatives were synthesized and evaluated their cytotoxicity. The structures of the synthesized compounds were established on the basis of spectral data. The in vitro antitumor activity of the synthesized c
Synthesis of halogen derivatives of benzo[h]chromene and benzo[a]anthracene with promising antimicrobial activities.
Khafagy, Mostafa M,Abd el-Wahab, Ashraf H F,Eid, Fathy A,el-Agrody, Ahmed M
, p. 715 - 722 (2007/10/03)
The synthesis of novel 7-(4-halophenyl)-8,9-dihydro-7H-12-oxa-9,11-diaza-benzo[a]anthracene derivatives has been reported. The key intermediate 3-amino-9-chloro-1-(4-halophenyl)-1H-benzo[h]chromene-2-carbonitrile (3) was obtained by treating 4-halobenzylidenmalononitriles (1a-c) and ethyl 4-halobenzylidenmalonates (1d-f) with 4-chloro-1-naphthol (2) in ethanolic piperidine solution. Antimicrobial activity was shown for most of the synthesized compounds.
