158168-60-6

Basic information

• Product Name: 4-nitrobenzyl (1 R ,5 S ,6 S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate
• Synonyms: 4-nitrobenzyl (1 R ,5 S ,6 S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate
• CAS NO: 158168-60-6
• Molecular Weight: 553.636
• Mol File: 158168-60-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-nitrobenzyl (1 R ,5 S ,6 S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-nitrobenzyl (1 R ,5 S ,6 S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate(158168-60-6)
• EPA Substance Registry System: 4-nitrobenzyl (1 R ,5 S ,6 S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate(158168-60-6)

Safety Data

• Hazardous Substances Data: 158168-60-6(Hazardous Substances Data)

Upstream product

• 156263-91-1 4-nitrobenzyl (1R,5S,6S)-2-(2-diethylcarbamoylphenylthio)-1-methyl-6-[1(R)-trimethylsilyloxyethyl]-1-carbapen-2-em-3-carboxylate 
• 5949-29-1 citric acid monohydrate 

Downstream Products

• 158250-79-4 4-Nitrobenzyl (1R,5S,6S)-2-(2-diethylcarbamoyl-phenylsulphinyl)-1-methyl-6-[1(R)-hydroxyethyl]-1-carbapen-2-em-3-carboxylate 
• 96036-02-1 p-nitrobenzyl (4R,5S,6S)-3-<(3S,5S)-5-dimethylaminocarbonyl-1-(p-nitrobenzyloxycarbonyl)pyrrolidin-3-ylthio>-6-<(1R)-1-hydroxyethyl>-4-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-en-2-carboxylate 

Relevant articles and documents

Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds

Compounds of formula (I): STR1 wherein: R1 is hydrogen or a hydroxy-protecting group; R2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R3 is optionally substituted pyridyl, optionally substituted quinolyl or phenyl group which has a substituent of formula --CYNR5 R6, where Y is oxygen or sulfur, and R5 and R6 are each alkyl, aryl or aralkyl, or R5 and R6 and the nitrogen to which they are attached together form a heterocyclic group; is R4 hydrogen or an amino-protecting group; and Z is sulfur or oxygen; are valuable intermediates in the preparation of carbapenem compounds and retain a desirable configuration during conversion to such carbapenem compounds. Penem and carbapenem compounds having a group of formula --SA' are prepared from a corresponding compound having a substituted thio, sulfinyl or sulfonyl group at this position by reaction with a compound A'SH (where A' is an organic group) in the presence of a salt of a metal of Group II or III of the Periodic Table.