1581756-86-6

Basic information

• Product Name: 4-chloro-N-[2-(pyridin-2-yl)phenyl]benzamide
• Synonyms: 4-chloro-N-[2-(pyridin-2-yl)phenyl]benzamide
• CAS NO: 1581756-86-6
• Molecular Weight: 308.767
• Mol File: 1581756-86-6.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 4-chloro-N-[2-(pyridin-2-yl)phenyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N-[2-(pyridin-2-yl)phenyl]benzamide(1581756-86-6)
• EPA Substance Registry System: 4-chloro-N-[2-(pyridin-2-yl)phenyl]benzamide(1581756-86-6)

Safety Data

• Hazardous Substances Data: 1581756-86-6(Hazardous Substances Data)

Upstream product

• 1008-89-5 2-phenylpyridine 
• 1613-88-3 4-chloro-N-hydroxybenzamide 
• 25563-14-8 4-chloro-N-methoxybenzamide 
• 191171-55-8 2-anilineboronic acid pinacol ester 
• 615-36-1 2-bromoaniline 
• 76426-76-1 N-[2-(pyridine-2-yl)phenyl]benzamide 
• 29528-30-1 2-(2-pyridyl)aniline 
• 122-01-0 4-chloro-benzoyl chloride 
• 186298-88-4 4-Chloro-N-(3-oxo-3H-1λ³-benzo[d][1,2]iodoxol-1-yl)-benzamide 
• 495-18-1 Benzohydroxamic acid 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 132401-91-3 3-(4-chlorophenyl)-1,4,2-dioxazol-5-one 
• 21368-28-5 4-chlorobenzoyl azide 

Relevant articles and documents

Chemical Upcycling of Waste Poly(bisphenol A carbonate) to 1,4,2-Dioxazol-5-ones and One-Pot C?H Amidation

Chemical upcycling of poly(bisphenol A carbonate) (PC) was achieved in this study with hydroxamic acid nucleophiles, giving rise to synthetically valuable 1,4,2-dioxazol-5-ones and bisphenol A. Using 1,5,7-triazabicyclo[4.4.0]-dec-5-ene (TBD), non-green carbodiimidazole or phosgene carbonylation agents used in conventional dioxazolone synthesis were successfully replaced with PC, and environmentally harmful bisphenol A was simultaneously recovered. Assorted hydroxamic acids exhibited good-to-excellent efficiencies and green chemical features, promising broad synthetic application scope. In addition, a green aryl amide synthesis process was developed, involving one-pot depolymerization from polycarbonate to dioxazolone followed by rhodium-catalyzed C?H amidation, including gram-scale examples with used compact discs.

[Cp*RhIII]/Ionic Liquid as a Highly Efficient and Recyclable Catalytic Medium for C?H Amidation

A [Cp*RhIII]-catalyzed direct C?H amidation is carried out in ionic liquid. Both C(sp2)?H bonds of (hetero)arenes and alkenes and unactivated C(sp3)?H bonds can be easily amidated with high functional-group tolerance and excellent yields under these conditions. Notably, using [Cp*RhIII]/[BMIM]BF4 (BMIM=1-butyl-3-methylimidazolium) as the green and recyclable medium is environmentally benign, in light of characteristics such as the reusability of the expensive rhodium catalyst, avoidance of highly toxic organic solvents, and mild reaction conditions, as well as a short reaction time.

Discovery of 2-(pyridin-2-yl)aniline as a directing group for the sp2 C-H bond amination mediated by cupric acetate

2-(Pyridin-2-yl) aniline was designed as a new, removable directing group in promoting C-H amination mediated by cupric acetate. Employing this auxiliary, the β-C(sp2)-H bonds of benzamide derivatives can be effectively aminated with a variety of amines in moderate to good yields with good functional group tolerance in air. In addition, the quinazolinone derivatives were isolated from the reaction mixture of N-(2-(pyridin-2-yl)phenyl)benzamide with formamide or 5-nitroindole. The corresponding mechanism is discussed. These results indicate that 2-(pyridine-2-yl)aniline can serve as a directing group.