158183-05-2

Basic information

• Product Name: TAEM
• Synonyms: S-2-BENZOTHIAZOLYL-(Z)-2-(TERT-BUTOXYCARBONYL-ISOPROPOXYIMINO)THIOACETATE BENZOTHIAZOLE ESTER;TAEM;(Z)-2-(2-aminothiazol-4-yl)-2-(2-t-butoxycarbonylprop-2-oxyimino) acetate;2-Mercaptobenzothiazolyl;Ceftazidime intermediate;2-Mercaptobenzothiazoyl-(Z)-2-(2-Aminothiazole-4-yl)-2-(tert-butoxycarbonylprop;2-Mercaptobenzothiazoyl-(Z)-2-(2-Amino-Thiazole-4-Yl)-2-(Tert-Butoxycarbonyl)Isopropoxyimino Acetate;2-Mercaptobenzothiazolyl(Z)-2-(2-aminothiazol-4-yl)-2-(2-t-butoxycarbonylprop-2-oxyimino)acetate TAEM
• CAS NO: 158183-05-2
• Molecular Formula: C20H22N4O4S3
• Molecular Weight: 478.61
• EINECS: 1312995-182-4
• Mol File: 158183-05-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 138-140℃
• Boiling Point: 621.6°C at 760 mmHg
• Flash Point: 329.7°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 2.26E-15mmHg at 25°C
• Refractive Index: 1.671
• PKA: 1.89±0.10(Predicted)
• CAS DataBase Reference: TAEM(CAS DataBase Reference)
• NIST Chemistry Reference: TAEM(158183-05-2)
• EPA Substance Registry System: TAEM(158183-05-2)

Safety Data

• Statements: R53:
• Safety Statements: S61:
• Hazardous Substances Data: 158183-05-2(Hazardous Substances Data)

Usage

General Description

TAEM, also known as tetraaminoethylenemonoselenium dichloride, is a chemical compound that contains the elements carbon, hydrogen, nitrogen, chlorine, and selenium. It is a complex chelating agent that has been studied for its potential use in the treatment of certain types of cancer and as a contrast agent in medical imaging. TAEM has also been investigated for its potential antioxidant and antimicrobial properties. Studies have shown that TAEM may have the ability to bind to metal ions in the body, which could make it useful for chelation therapy in cases of heavy metal poisoning. Additionally, its potential use in the development of new materials and as a catalyst in chemical reactions has also been explored.

InChI:InChI=1/C20H22N4O4S3/c1-19(2,3)27-16(26)20(4,5)28-24-14(12-10-29-17(21)22-12)15(25)31-18-23-11-8-6-7-9-13(11)30-18/h6-10H,1-5H3,(H2,21,22)/b24-14-

Upstream product

• 120-78-5 di(benzothiazol-2-yl)disulfide 
• 86299-47-0 (Z)-2-(2-aminothiazol-4-yl)-2-(1-tert-butoxycarbonyl-1-methylethoxy)iminoacetic acid 

Downstream Products

• 102772-66-7 (Z)-7-(2-(2-aminothiazol-4-yl)-2-(((1-(tertbutoxy)-2-methyl-1-oxopropan-2-yl)oxy)amino)acetamido)-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylate 

Relevant articles and documents

PRODRUG INHIBITORS

Provided herein are compounds useful as metallo-β-lactamase (MBL) inhibitors. The compounds have a formula A–B, where A is a β-lactam antibiotic moiety comprising a bridging methylene (-CH2-) covalently attached to -B; and B is a latent MBL inhibitor. Also provided are formulations comprising such compounds; as well as such compounds or formulations for use as a medicament. The compounds and formulations may be used in the treatment of antibiotic resistance, bacterial infection. The compounds and formulations may be used in the inhibition of a bacterial MBL.

Green process for synthesizing ceftazidime side-chain active ester by using microwave-assisted method

The invention belongs to the technical field of medicines and in particular relates to a green process for synthesizing a ceftazidime side-chain active ester by using a microwave-assisted method. The green process comprises the following steps: by taking a ceftazidime side-chain acid and dithio-bisbenzothiazole as raw materials, and a mixed solution of benzene and acetonitrile as a solvent, under the catalysis of a composite alkali catalyst, dropwise adding triethyl phosphate, performing a microwave-assisted reaction by using a microwave reactor, and performing aftertreatment after the reaction is completed, thereby obtaining a product, wherein the microwave radiation power is 80-300W, and the radiation time is 30-60 minutes. As triethyl phosphate which is low in price is adopted to replace triphenylphosphine which is high in price in the prior art, the production cost can be reduced. The green process for synthesizing the ceftazidime side-chain active ester by using the microwave-assisted method, which is provided by the invention, is low in cost, the production capacity is greatly increased, the yield is increased, that is, up to 97% or greater, the prepared product is relatively high in purity, that is, up to 99% or greater, and a pleasantly surprised technical effect is achieved.